Main conclusion <p><b>Nanofertilizers can enhance the efficiency of water and nutrient use. This study will explore the potential benefits of nanofertilizers in the context of the global water crisis.</b></p> Abstract <p>Water is essential for all living things to support biodiversity, food security, human life, and societal progress. The world is experiencing a water crisis due to the increasing scarcity of freshwater supplies caused by climate change. Reports indicate that both conventional and unconventional methods are being employed to address the global water crisis. The use of natural resources is under stress because of the massive growth in the human population over the past few decades. To meet this need, chemical fertilizers are being used to enhance crop yields, but this has negative ecological consequences. Thus, the time has come to replace conventional farming methods with sensible ones that will boost food production and nutritional content without threatening our ecosystem. In this regard, achieving sustainability can be accomplished by applying innovative, cutting-edge technologies such as nanotechnology. Nanofertilizers (NFs) are among the most promising synthetic materials for sustaining agricultural yields through intelligent agrochemical release. Unlike the global water crisis, nanofertilizers possess unique properties that can enhance the efficiency of water use in cultivated crops, particularly under stressful conditions. This study offers a wealth of information about the direct and indirect characteristics of nanofertilizers and their potential impacts on the water crisis. In conclusion, there is a pressing need for more research on this significant global issue, especially considering the serious concerns surrounding climate change.</p>