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<p>Pancreatic α-cells play a key role in glucose homeostasis through glucagon secretion. Here, we discover that the bile acid-sensitive ion channel (BASIC), a Na<sup>+</sup> channel of the DEG/ENaC family, has a hitherto unrecognized role in α-cell function. We found that BASIC is mainly expressed in glucagon-positive α-cells of mouse islets. Genetic ablation of BASIC in mice reduced α-cell number, glucagon expression, and glucagon serum levels. These dramatic changes were accompanied by disturbed expression of α-cell specific transcription factors. Our findings identify BASIC as a previously unknown regulator of α-cell physiology.</p>

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The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Jingyu Yang,
  • Stefan Gründer,
  • Dominik Wiemuth

摘要

Pancreatic α-cells play a key role in glucose homeostasis through glucagon secretion. Here, we discover that the bile acid-sensitive ion channel (BASIC), a Na+ channel of the DEG/ENaC family, has a hitherto unrecognized role in α-cell function. We found that BASIC is mainly expressed in glucagon-positive α-cells of mouse islets. Genetic ablation of BASIC in mice reduced α-cell number, glucagon expression, and glucagon serum levels. These dramatic changes were accompanied by disturbed expression of α-cell specific transcription factors. Our findings identify BASIC as a previously unknown regulator of α-cell physiology.