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<p>The 2025 Nobel prize in Medicine or Physiology was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for unravelling the basis of peripheral immune tolerance: regulatory T (Treg) cells. Treg cells are a subset of CD4<sup>+</sup> T helper cells characterized by the expression of the transcription factor <i>Foxp3</i> and the surface receptor CD25 (IL-2 receptor alpha subunit) and are key for maintaining immune homeostasis and preventing autoimmunity. In this minireview, we trace the discovery of Treg cells, their phenotype and function and how these findings are employed in generating safer and more efficient therapies for autoimmune diseases and cancer.</p>

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From chaos to control: Nobel insights in regulatory T cells and immune tolerance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Anna Estrada Brull,
  • Nicole Joller

摘要

The 2025 Nobel prize in Medicine or Physiology was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for unravelling the basis of peripheral immune tolerance: regulatory T (Treg) cells. Treg cells are a subset of CD4+ T helper cells characterized by the expression of the transcription factor Foxp3 and the surface receptor CD25 (IL-2 receptor alpha subunit) and are key for maintaining immune homeostasis and preventing autoimmunity. In this minireview, we trace the discovery of Treg cells, their phenotype and function and how these findings are employed in generating safer and more efficient therapies for autoimmune diseases and cancer.