Scholarlink

Background <p>Roux-en-Y gastric bypass (RYGB) is associated with substantial weight loss and improved obesity-related comorbidities. However, outcomes on body composition, particularly skeletal muscle (SM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) remain inconsistent due to limitations in measurement techniques.</p> Objective <p>Evaluate longitudinal changes in SM, VAT, and SAT volumes (cm<sup>3</sup>) following RYGB using Data Analysis Facilitation Suite (DAFS), an automated computed tomography (CT) analysis software.</p> Methods <p>In this prospective pilot study, nine female patients underwent low-dose abdominal and pelvic CT imaging at baseline, 3-, and 6-months post-RYGB. Volumetric analysis from the ninth thoracic veterbra (T9) to the sacrum was performed using DAFS. Changes in SM, VAT, and SAT were assessed using paired t-tests.</p> Results <p>Participants (mean ± SD; age 35 ± 9 years, BMI 48 ± 10&#xa0;kg/m²) experienced substantial weight loss (14 ± 5% at 3 months, 25 ± 7% at 6 months; <i>p</i> &lt; 0.001). SAT and VAT volumes decreased significantly by 21% and 27% at 3 months, and by 31% and 47% at 6 months, respectively (all <i>p</i> &lt; 0.001). In contrast, SM volume showed a significant decline of 14% at month 3 (<i>p</i> &lt; 0.001) and then plateaued thereafter.</p> Conclusion <p>The changes over time differ substantially among SM, VAT and SAT after Roux-en-Y gastric bypass, reflecting the distinct physiological responses and metabolic improvement of different tissue types. Larger and longer clinical studies are needed to validate these findings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Longitudinal analysis of body compositions following Roux-en-Y gastric bypass

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月21日

查看全文
  • Zubaidah Nor Hanipah,
  • Gabriela de O. Lemos,
  • Sophia Ramirez,
  • Venkata Satya Naga Arun Kousik Dhulipala,
  • Karteek Popuri,
  • Mirza Faisal Beg,
  • Shengping Yang,
  • Philip R. Schauer,
  • Vance L. Albaugh,
  • Steven B. Heymsfield

摘要

Background

Roux-en-Y gastric bypass (RYGB) is associated with substantial weight loss and improved obesity-related comorbidities. However, outcomes on body composition, particularly skeletal muscle (SM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) remain inconsistent due to limitations in measurement techniques.

Objective

Evaluate longitudinal changes in SM, VAT, and SAT volumes (cm3) following RYGB using Data Analysis Facilitation Suite (DAFS), an automated computed tomography (CT) analysis software.

Methods

In this prospective pilot study, nine female patients underwent low-dose abdominal and pelvic CT imaging at baseline, 3-, and 6-months post-RYGB. Volumetric analysis from the ninth thoracic veterbra (T9) to the sacrum was performed using DAFS. Changes in SM, VAT, and SAT were assessed using paired t-tests.

Results

Participants (mean ± SD; age 35 ± 9 years, BMI 48 ± 10 kg/m²) experienced substantial weight loss (14 ± 5% at 3 months, 25 ± 7% at 6 months; p < 0.001). SAT and VAT volumes decreased significantly by 21% and 27% at 3 months, and by 31% and 47% at 6 months, respectively (all p < 0.001). In contrast, SM volume showed a significant decline of 14% at month 3 (p < 0.001) and then plateaued thereafter.

Conclusion

The changes over time differ substantially among SM, VAT and SAT after Roux-en-Y gastric bypass, reflecting the distinct physiological responses and metabolic improvement of different tissue types. Larger and longer clinical studies are needed to validate these findings.