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Objective <p>This study is aiming at analyzing the effects of intercostal nerve block preemptive analgesia and incisional infiltration anesthesia on postoperative pain in patients undergoing laparoscopic cholecystectomy.</p> Methods <p>Ninety patients who underwent laparoscopic cholecystectomy were retrospectively selected. According to different anesthesia methods, they were allocated into an intervention group and a control group, with 45 patients in each. The control group received incisional infiltration anesthesia alone, while the intervention group received intercostal nerve block with preemptive anesthesia combined with incisional infiltration. Pain intensity was assessed using the Visual Analogue Scale (VAS) at 4, 8, 12, and 24&#xa0;h postoperatively at rest, and during mobilization at 8, 12, and 24&#xa0;h. Postoperative analgesia conditions, as well as the operative time, length of hospital stay, time to first ambulation, and awakening time of the two groups, were compared. The incidence of adverse events was also compared.</p> Results <p>The intervention group reported lower resting VAS scores at 4, 8, 12, and 24&#xa0;h and lower movement-related VAS scores at 8, 12, and 24&#xa0;h (all <i>P</i> &lt; 0.05). The number of cases with VAS ≥ 4 at 4&#xa0;h, 8&#xa0;h, 12&#xa0;h, and 24&#xa0;h postoperatively in the control group was higher than that in the intervention group (<i>P</i> = 0.020, 0.033, 0.034, 0.019). Moreover, the proportion of patients who did not receive additional tramadol in the intervention group was higher at 4&#xa0;h, 8&#xa0;h, 12&#xa0;h, and 24&#xa0;h postoperatively [2/13 (15.38%) vs. 2/24 (8.33%); 5/16 (31.25%) vs. 3/28 (10.71%); 7/13 (53.85%) vs. 4/26 (15.38%); 4/10 (40.00%) vs. 3/22 (13.64%)]. There was no significant difference in the operative time between the two groups (<i>P</i> = 0.065). The length of hospital stay, time to first ambulation, and awakening time in the intervention group were all shorter than those in the control group (<i>P</i> &lt; 0.05). The incidence of adverse events did not differ significantly between groups (8.89% vs. 13.33%, <i>P</i> = 0.739).</p> Conclusion <p>Preemptive analgesia with intercostal nerve block &amp; incisional infiltration anesthesia offers effective pain control in laparoscopic cholecystectomy, reducing the use of postoperative drugs, with a favorable safety profile.</p>

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Influence of intercostal nerve block preemptive analgesia and incisional infiltration anesthesia on postoperative pain in patients undergoing laparoscopic cholecystectomy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月30日

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  • Ling Zhao,
  • Yuxin Zhang,
  • Xinde Chen,
  • Chunyuan Zhang

摘要

Objective

This study is aiming at analyzing the effects of intercostal nerve block preemptive analgesia and incisional infiltration anesthesia on postoperative pain in patients undergoing laparoscopic cholecystectomy.

Methods

Ninety patients who underwent laparoscopic cholecystectomy were retrospectively selected. According to different anesthesia methods, they were allocated into an intervention group and a control group, with 45 patients in each. The control group received incisional infiltration anesthesia alone, while the intervention group received intercostal nerve block with preemptive anesthesia combined with incisional infiltration. Pain intensity was assessed using the Visual Analogue Scale (VAS) at 4, 8, 12, and 24 h postoperatively at rest, and during mobilization at 8, 12, and 24 h. Postoperative analgesia conditions, as well as the operative time, length of hospital stay, time to first ambulation, and awakening time of the two groups, were compared. The incidence of adverse events was also compared.

Results

The intervention group reported lower resting VAS scores at 4, 8, 12, and 24 h and lower movement-related VAS scores at 8, 12, and 24 h (all P < 0.05). The number of cases with VAS ≥ 4 at 4 h, 8 h, 12 h, and 24 h postoperatively in the control group was higher than that in the intervention group (P = 0.020, 0.033, 0.034, 0.019). Moreover, the proportion of patients who did not receive additional tramadol in the intervention group was higher at 4 h, 8 h, 12 h, and 24 h postoperatively [2/13 (15.38%) vs. 2/24 (8.33%); 5/16 (31.25%) vs. 3/28 (10.71%); 7/13 (53.85%) vs. 4/26 (15.38%); 4/10 (40.00%) vs. 3/22 (13.64%)]. There was no significant difference in the operative time between the two groups (P = 0.065). The length of hospital stay, time to first ambulation, and awakening time in the intervention group were all shorter than those in the control group (P < 0.05). The incidence of adverse events did not differ significantly between groups (8.89% vs. 13.33%, P = 0.739).

Conclusion

Preemptive analgesia with intercostal nerve block & incisional infiltration anesthesia offers effective pain control in laparoscopic cholecystectomy, reducing the use of postoperative drugs, with a favorable safety profile.