Objective <p>To assess the application of laparoscopic cholecystectomy (LC), such as safety, feasibility, and advantages via Laennec’s capsule in patients with gallbladder stones complicated by acute cholecystitis.</p> Methods <p>A total of 120 patients with gallbladder stones and acute cholecystitis who underwent surgery at Lishui District People’s Hospital, Nanjing, from June 2022 to August 2024 were retrospectively assessed. Patients were divided into the following two groups: the experimental (LC via the Laennec’s capsule, <i>n</i> = 60) and control groups (conventional LC with Calot’s triangle dissection, <i>n</i> = 60). The parameters such as the intraoperative blood loss, operative time, duration of postoperative drainage, length of hospital stay, bile duct injury rate, conversion to open surgery, the rate of postoperative complications, use of bioabsorbable clips, and gastrointestinal recovery were recorded. The enzyme-linked immunosorbent assay was used to measure serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels.</p> Results <p>The experimental group demonstrated significantly lower intraoperative blood loss, shorter duration of postoperative drainage, faster gastrointestinal recovery, shorter hospital stay, lower postoperative pain scores, and reduced use of bioabsorbable clips than the control group (<i>p</i> &lt; 0.05). Serum IL-6 and CRP levels in the experimental group were significantly lower at 24&#xa0;h postoperatively than those in the control group. However, no statistically significant differences were observed between the experimental and control groups in terms of baseline characteristics, operative time, conversion to open surgery rate, or postoperative complication rate (<i>p</i> &gt; 0.05).</p> Conclusion <p>LC via the Laennec’s capsule offers advantages by accelerating gastrointestinal recovery, reducing the postoperative inflammatory response, and improving quality of life in the treatment of gallbladder stone patients with acute cholecystitis.</p>