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Purpose <p>We aimed to develop a novel fluorescent surgical gauze dyed with indocyanine green (ICG) to guide surgeons to the target anatomical destination during surgery for real-time navigation and to prevent gauze remnants after surgery.</p> Methods <p>Surgical gauze was dyed with an aqueous solution of ICG (5.0 × 10<sup>− 5</sup> mol L<sup>− 1</sup> for Steraze, 1.5 × 10<sup>− 4</sup> mol L<sup>− 1</sup> for BK-Opeze) at 132&#xa0;°C (inside pressure: 2.82&#xa0;atm, 286&#xa0;kPa) for 15&#xa0;min using an autoclave, followed by washing with distilled water, drying at room temperature, and sterilizing at 132&#xa0;°C for 8&#xa0;min before surgery. Fluorescence (FL) intensity was examined preclinically in the resected specimens using the SPY PHI (Stryker) system. Fourteen patients who underwent laparoscopic- and robotic-assisted gastroenterological surgery at Showa University Hospital were included.</p> Results <p>Fluorescent emission of ICG-dyed gauze was clearly observed through resected specimens with a thickness of approximately 10&#xa0;mm or more. In a clinical trial, the ICG-dyed gauze was detected earlier with near-infrared (near-IR) FL imaging than under white light during seven cases of laparoscopic and robotic surgery, which could become a precise marker for surgeons to locate the dissection site despite overlaying tissues and nearby disturbances. Additionally, no seepage of ICG from the gauze was observed in all surgical fields.</p> Conclusion <p>We successfully developed ICG-dyed gauze exhibiting bright near-IR FL which can guide surgeons to the target anatomical destination and prevent gauze remnants during surgery. This invention would be a powerful support for real-time navigation surgery.</p>

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Indocyanine green dyed gauze-guided minimum invasive surgery for anatomical landmarks and preventing gauze remnants: a pilot study

  • 期刊论文

  • 发表日期：

    2025年1月15日

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  • Yoshihiko Tashiro,
  • Takeshi Aoki,
  • Hidekazu Yasunaga,
  • Shinji Ando

摘要

Purpose

We aimed to develop a novel fluorescent surgical gauze dyed with indocyanine green (ICG) to guide surgeons to the target anatomical destination during surgery for real-time navigation and to prevent gauze remnants after surgery.

Methods

Surgical gauze was dyed with an aqueous solution of ICG (5.0 × 10− 5 mol L− 1 for Steraze, 1.5 × 10− 4 mol L− 1 for BK-Opeze) at 132 °C (inside pressure: 2.82 atm, 286 kPa) for 15 min using an autoclave, followed by washing with distilled water, drying at room temperature, and sterilizing at 132 °C for 8 min before surgery. Fluorescence (FL) intensity was examined preclinically in the resected specimens using the SPY PHI (Stryker) system. Fourteen patients who underwent laparoscopic- and robotic-assisted gastroenterological surgery at Showa University Hospital were included.

Results

Fluorescent emission of ICG-dyed gauze was clearly observed through resected specimens with a thickness of approximately 10 mm or more. In a clinical trial, the ICG-dyed gauze was detected earlier with near-infrared (near-IR) FL imaging than under white light during seven cases of laparoscopic and robotic surgery, which could become a precise marker for surgeons to locate the dissection site despite overlaying tissues and nearby disturbances. Additionally, no seepage of ICG from the gauze was observed in all surgical fields.

Conclusion

We successfully developed ICG-dyed gauze exhibiting bright near-IR FL which can guide surgeons to the target anatomical destination and prevent gauze remnants during surgery. This invention would be a powerful support for real-time navigation surgery.