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Purpose <p>Acute physical exercise triggers a transient immune response. For endurance exercise, these effects are intensity-dependent. In contrast, the role of exercise intensity in resistance exercise (RE) and its contribution to immune modulation remains less understood. This randomised crossover trial aims to compare the acute effects of High-Intensity Interval Resistance Exercise (HIIRE) versus Low-Intensity Resistance Exercise (LIRE) on routine clinical cellular inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)—in 24 healthy, RE-trained young men.</p> Methods <p>Measurements were taken at baseline (T<sub>0</sub>), immediately post-exercise (T<sub>1</sub>), and 45&#xa0;min post-exercise (T<sub>2</sub>). It was hypothesised that HIIRE would elicit a significantly greater increase in NLR, PLR, and SII from baseline (T<sub>0</sub>) to post-exercise (T<sub>1</sub> and T<sub>2</sub>) compared to LIRE.</p> Results <p>Baseline-adjusted ANCOVAs revealed significant interactions for cellular inflammatory markers (<i>η</i><sup>2</sup><sub>p</sub> = .072; NLR: <i>p</i> &lt; .001, <i>η</i><sup>2</sup><sub>p</sub> = .217; PLR: <i>p</i> &lt; .001, <i>η</i><sup>2</sup><sub>p</sub> = .147; SII: <i>p</i> &lt; .001, <i>η</i><sup>2</sup><sub>p</sub> = .204). Post hoc analyses locate this difference for NLR, PLR, and SII 45&#xa0;min post-exercise, with greater increases of HIIRE.</p> Conclusion <p>The results suggest a complex immune response involving pro-inflammatory signalling and immune cell redistribution induced by acute RE, with intensity being a main driver. This underscores the pivotal role of intensity in modulating acute immune responses to RE, with potential implications for exercise prescription targeting inflammatory processes.</p>

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Intensity matters: high-intensity interval resistance exercise induces greater immune activation than low-intensity resistance exercise 45 min post-workout

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月16日

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  • Fabian Fabritius,
  • Matthias Rißmayer,
  • Miriam Ringleb,
  • Niklas Joisten,
  • Wilhelm Bloch,
  • Finn Dreisigacker,
  • Florian Javelle

摘要

Purpose

Acute physical exercise triggers a transient immune response. For endurance exercise, these effects are intensity-dependent. In contrast, the role of exercise intensity in resistance exercise (RE) and its contribution to immune modulation remains less understood. This randomised crossover trial aims to compare the acute effects of High-Intensity Interval Resistance Exercise (HIIRE) versus Low-Intensity Resistance Exercise (LIRE) on routine clinical cellular inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)—in 24 healthy, RE-trained young men.

Methods

Measurements were taken at baseline (T0), immediately post-exercise (T1), and 45 min post-exercise (T2). It was hypothesised that HIIRE would elicit a significantly greater increase in NLR, PLR, and SII from baseline (T0) to post-exercise (T1 and T2) compared to LIRE.

Results

Baseline-adjusted ANCOVAs revealed significant interactions for cellular inflammatory markers (η2p = .072; NLR: p < .001, η2p = .217; PLR: p < .001, η2p = .147; SII: p < .001, η2p = .204). Post hoc analyses locate this difference for NLR, PLR, and SII 45 min post-exercise, with greater increases of HIIRE.

Conclusion

The results suggest a complex immune response involving pro-inflammatory signalling and immune cell redistribution induced by acute RE, with intensity being a main driver. This underscores the pivotal role of intensity in modulating acute immune responses to RE, with potential implications for exercise prescription targeting inflammatory processes.