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Purpose <p>Diabetic tendinopathy is an underrecognized complication of type 2 diabetes. Despite glycemic control with antidiabetic drugs, tendon structure and function often remain impaired. Plant-derived bioactive compounds offer dual benefits by lowering blood glucose while targeting tendon-specific pathology. This study evaluated the therapeutic potential and underlying mechanisms of cuminaldehyde (CA) on Achilles tendon properties in a type 2 diabetic rat model induced by a high-fat diet (HFD) combined with low-dose streptozotocin (STZ).</p> Methods <p>A total of 24 male white Sprague-Dawley rats were randomly divided into four groups. Control (non-diabetic), diabetic (HFD + 35&#xa0;mg/kg STZ), diabetic rats treated with low-dose CA (5&#xa0;mg/kg), diabetic rats treated with high-dose CA (10&#xa0;mg/kg). After 2 weeks of diabetic induction, CA was given orally for 2 weeks.</p> Results <p>CA significantly ameliorated histological alterations in Achilles tendons and improved locomotor behavior in the open-field test. These effects were associated with restoration of superoxide dismutase (SOD) activity and suppression of <i>AGER</i> expression. <i>SCX</i> expression, which was initially reduced in diabetic rats, was restored following CA treatment in a dose-dependent manner.</p> Conclusion <p>CA demonstrates a high therapeutic potential in diabetic tendinopathy by restoring antioxidant defense and modulating <i>AGER</i>-related signaling pathways.</p>

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Cuminaldehyde alleviates rat diabetic tendinopathy and improves gait behavior via SOD restoration and AGER signaling axis inhibition

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Asiyeh Shojaee,
  • Mohammad Amin Mashayekhpour

摘要

Purpose

Diabetic tendinopathy is an underrecognized complication of type 2 diabetes. Despite glycemic control with antidiabetic drugs, tendon structure and function often remain impaired. Plant-derived bioactive compounds offer dual benefits by lowering blood glucose while targeting tendon-specific pathology. This study evaluated the therapeutic potential and underlying mechanisms of cuminaldehyde (CA) on Achilles tendon properties in a type 2 diabetic rat model induced by a high-fat diet (HFD) combined with low-dose streptozotocin (STZ).

Methods

A total of 24 male white Sprague-Dawley rats were randomly divided into four groups. Control (non-diabetic), diabetic (HFD + 35 mg/kg STZ), diabetic rats treated with low-dose CA (5 mg/kg), diabetic rats treated with high-dose CA (10 mg/kg). After 2 weeks of diabetic induction, CA was given orally for 2 weeks.

Results

CA significantly ameliorated histological alterations in Achilles tendons and improved locomotor behavior in the open-field test. These effects were associated with restoration of superoxide dismutase (SOD) activity and suppression of AGER expression. SCX expression, which was initially reduced in diabetic rats, was restored following CA treatment in a dose-dependent manner.

Conclusion

CA demonstrates a high therapeutic potential in diabetic tendinopathy by restoring antioxidant defense and modulating AGER-related signaling pathways.