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<p>The primary objective of this study was to determine the impact of whole-body periodic acceleration (WBPA) as a countermeasure on preventing bone loss caused by hindlimb unloading. 48 male Sprague Dawley rats were randomized into four groups: (1) control group (C, <i>n</i> = 12), (2) hindlimb unloading group (HU, <i>n</i> = 12), (3) hindlimb unloading + WBPA group (HU + WBPA, <i>n</i> = 12), and (4) hindlimb unloading + flat rest group (HU + FR, <i>n</i> = 12). WBPA consisted of 1&#xa0;h of acceleration stimulation, administered once daily using a specially designed training device. After 28 days of hindlimb unloading, Micro-CT analyses showed significant decreases in bone mineral density (BMD, <i>p</i> &lt; 0.0001), bone volume to tissue volume (BV/TV, <i>p</i> &lt; 0.0001), trabecular thickness (Tb.Th, <i>p</i> &lt; 0.0001) of femoral cancellous bone and cortical area (Ct.Ar, <i>p</i> &lt; 0.0001) of femoral cortical bone. The application of WBPA for 1&#xa0;h/day, significantly increased BMD (<i>p</i> &lt; 0.05), BV/TV (<i>p</i> &lt; 0.05) and Tb.Th (<i>p</i> &lt; 0.0001) of femoral cancellous bone, relative to HU. Three-point bending test of HU femurs showed reduced maximum load (<i>p</i> &lt; 0.0001), elastic load (<i>p</i> &lt; 0.0001) and energy absorption (N.mm) (<i>p</i> &lt; 0.0001). In comparison to HU, WBPA-treated bone showed increased maximum load (<i>p</i> &lt; 0.0001), elastic load (<i>p</i> &lt; 0.0001) and energy absorption (<i>p</i> &lt; 0.001). In summary, this study demonstrates the potential of WBPA as an innovative solution to combat bone loss caused by long-term hindlimb unloading.</p>

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Whole-body periodic acceleration: a new countermeasure against bone loss induced by long-term hindlimb unloading

  • 期刊论文

  • 发表日期：

    2025年12月24日

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  • Xuefeng Liu,
  • Jinlong Li,
  • Huijuan Wang,
  • Feng Wu,
  • Hailong Wang,
  • Kaijie Jiang,
  • Min Yuan,
  • Zi Xu,
  • Guanghan Kan,
  • Shujuan Liu,
  • Xiaoqian Dai,
  • Wenjiong Li,
  • Bo Wang,
  • Zhili Li

摘要

The primary objective of this study was to determine the impact of whole-body periodic acceleration (WBPA) as a countermeasure on preventing bone loss caused by hindlimb unloading. 48 male Sprague Dawley rats were randomized into four groups: (1) control group (C, n = 12), (2) hindlimb unloading group (HU, n = 12), (3) hindlimb unloading + WBPA group (HU + WBPA, n = 12), and (4) hindlimb unloading + flat rest group (HU + FR, n = 12). WBPA consisted of 1 h of acceleration stimulation, administered once daily using a specially designed training device. After 28 days of hindlimb unloading, Micro-CT analyses showed significant decreases in bone mineral density (BMD, p < 0.0001), bone volume to tissue volume (BV/TV, p < 0.0001), trabecular thickness (Tb.Th, p < 0.0001) of femoral cancellous bone and cortical area (Ct.Ar, p < 0.0001) of femoral cortical bone. The application of WBPA for 1 h/day, significantly increased BMD (p < 0.05), BV/TV (p < 0.05) and Tb.Th (p < 0.0001) of femoral cancellous bone, relative to HU. Three-point bending test of HU femurs showed reduced maximum load (p < 0.0001), elastic load (p < 0.0001) and energy absorption (N.mm) (p < 0.0001). In comparison to HU, WBPA-treated bone showed increased maximum load (p < 0.0001), elastic load (p < 0.0001) and energy absorption (p < 0.001). In summary, this study demonstrates the potential of WBPA as an innovative solution to combat bone loss caused by long-term hindlimb unloading.