Scholarlink

Purpose <p>Anabolic-Androgenic Steroid (AAS) use has been shown to impact the expression of myogenic growth factors. Very little of this research has been performed with human subjects, and none with athletes. This study investigated the effects of AAS use and iron sport training style on myogenic expression of the genes coding for insulin-like growth factor 1 (IGF1), myogenin (MYOG), and myoblast determination protein 1 (MyoD).</p> Methods <p>Fifty-two male iron sport athletes were classified as powerlifters (<i>n</i> = 21), body builders (<i>n</i> = 19), or strongmen (<i>n</i> = 12), and as AAS users (<i>n</i> = 18) or non-users (<i>n</i> = 34) via self-reported data. Saliva samples were collected to be analyzed for expression levels of IGF1, MYOG, and MyoD. Expression levels were analyzed via a 2 (AAS use) x 3 (iron sport) factorial multivariate analysis of variance (MANOVA).</p> Results <p>There was no mean vector difference on any combination of dependent variables (Pillai’s Trace = 0.087, <i>F</i>(6, 86) = 0.653, <i>p</i> = .688, <i>η</i><sub><i>p</i></sub><sup><i>2</i></sup> = 0.044), and no significant main effects for AAS use (Pillai’s Trace = 0.126, <i>F</i>(3, 42) = 2.026, <i>p</i> = .125, <i>η</i><sub><i>p</i></sub><sup><i>2</i></sup> = 0.126), or iron sport (Pillai’s Trace = 0.181, <i>F</i>(6, 86) = 1.422, <i>p</i> = .215, <i>η</i><sub><i>p</i></sub><sup><i>2</i></sup> = 0.090).</p> Conclusion <p>Neither AAS use nor iron sport training facilitate meaningful changes in myogenic growth factor expression relative to each other. Future researchers should investigate the effects of variables such as training age, length of AAS history, or expression of myogenic inhibitors such as myostatin.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The effects of anabolic-androgenic steroid use and training style on myogenic expression in trained male iron sport athletes

  • 期刊论文

  • 发表日期：

    2025年12月19日

查看全文
  • Luke M. Pelton,
  • Nicholas J. Coker,
  • Elizabeth M. Mullin,
  • Jennifer B. Fields

摘要

Purpose

Anabolic-Androgenic Steroid (AAS) use has been shown to impact the expression of myogenic growth factors. Very little of this research has been performed with human subjects, and none with athletes. This study investigated the effects of AAS use and iron sport training style on myogenic expression of the genes coding for insulin-like growth factor 1 (IGF1), myogenin (MYOG), and myoblast determination protein 1 (MyoD).

Methods

Fifty-two male iron sport athletes were classified as powerlifters (n = 21), body builders (n = 19), or strongmen (n = 12), and as AAS users (n = 18) or non-users (n = 34) via self-reported data. Saliva samples were collected to be analyzed for expression levels of IGF1, MYOG, and MyoD. Expression levels were analyzed via a 2 (AAS use) x 3 (iron sport) factorial multivariate analysis of variance (MANOVA).

Results

There was no mean vector difference on any combination of dependent variables (Pillai’s Trace = 0.087, F(6, 86) = 0.653, p = .688, ηp2 = 0.044), and no significant main effects for AAS use (Pillai’s Trace = 0.126, F(3, 42) = 2.026, p = .125, ηp2 = 0.126), or iron sport (Pillai’s Trace = 0.181, F(6, 86) = 1.422, p = .215, ηp2 = 0.090).

Conclusion

Neither AAS use nor iron sport training facilitate meaningful changes in myogenic growth factor expression relative to each other. Future researchers should investigate the effects of variables such as training age, length of AAS history, or expression of myogenic inhibitors such as myostatin.