Scholarlink

Purpose <p>Strength-related exerkines may be promoted in response to exercise imposing high mechanical stress on the skeletal muscles. For a constant velocity, the inclination of the slope during downhill exercise influences the total mechanical load. The aim of the study was to compare exerkines release following two prolonged decline walking (-10% and -20%) exercise session.</p> Methods <p>Twelve moderately active healthy men (age: 23.3 ± 3.6&#xa0;years; mass: 70.0 ± 4.5&#xa0;kg; height: 177.2 ± 2.9&#xa0;cm; body fat: 13.1 ± 3.2%) performed two 45-min downhill treadmill exercises at -10% (DOWN10) and -20% (DOWN20) slopes at the same pace (6&#xa0;km.h<sup>−1</sup>). Heart rate and muscle oxygenation were monitored during exercise and blood samples were taken before, 1&#xa0;h and 24&#xa0;h after exercise.</p> Results <p>Heart rate and muscle oxygenation were respectively greater and lower during DOWN20 exercise than DOWN10. Myostatin (MSTN; DOWN10 p ≤ 0.01 and DOWN20 p ≤ 0.05) and interleukine-6 (DOWN10 and DOWN20 p ≤ 0.001) levels increased 1&#xa0;h-post exercise in both conditions while no difference was found for decorin, follistatin and the growth differentiation factor-15 levels. No difference on exerkines release was evidenced between −&#xa0;10% and −&#xa0;20% treadmill slope but a significant condition effect between DOWN20 and DOWN10 was observed for DCN (p ≤ 0.05).</p> Conclusion <p>A 45-min downhill walking exercise at a −&#xa0;10% slope represents a valid strategy to stimulate the cardiovascular and muscular functions, as inferred from the increase in MSTN and IL-6 exerkines levels, and the use of a steepest slope protocol is no a prerequisite to elicit greater responses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of an acute bout of endurance eccentric exercise on exerkines production in healthy males

  • 期刊论文

  • 发表日期：

    2025年10月16日

查看全文
  • Trévis Carlet,
  • Fabrice Rannou,
  • Bruno Pereira,
  • Mikhail Kellawan,
  • Hugo Maxwell Pereira,
  • Gaël Ennequin,
  • Yoann Garnier

摘要

Purpose

Strength-related exerkines may be promoted in response to exercise imposing high mechanical stress on the skeletal muscles. For a constant velocity, the inclination of the slope during downhill exercise influences the total mechanical load. The aim of the study was to compare exerkines release following two prolonged decline walking (-10% and -20%) exercise session.

Methods

Twelve moderately active healthy men (age: 23.3 ± 3.6 years; mass: 70.0 ± 4.5 kg; height: 177.2 ± 2.9 cm; body fat: 13.1 ± 3.2%) performed two 45-min downhill treadmill exercises at -10% (DOWN10) and -20% (DOWN20) slopes at the same pace (6 km.h−1). Heart rate and muscle oxygenation were monitored during exercise and blood samples were taken before, 1 h and 24 h after exercise.

Results

Heart rate and muscle oxygenation were respectively greater and lower during DOWN20 exercise than DOWN10. Myostatin (MSTN; DOWN10 p ≤ 0.01 and DOWN20 p ≤ 0.05) and interleukine-6 (DOWN10 and DOWN20 p ≤ 0.001) levels increased 1 h-post exercise in both conditions while no difference was found for decorin, follistatin and the growth differentiation factor-15 levels. No difference on exerkines release was evidenced between − 10% and − 20% treadmill slope but a significant condition effect between DOWN20 and DOWN10 was observed for DCN (p ≤ 0.05).

Conclusion

A 45-min downhill walking exercise at a − 10% slope represents a valid strategy to stimulate the cardiovascular and muscular functions, as inferred from the increase in MSTN and IL-6 exerkines levels, and the use of a steepest slope protocol is no a prerequisite to elicit greater responses.