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Background <p>High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (e.g.,&#xa0;glucose control) that is observed after a night of inadequate sleep. It is unknown whether moderate-intensity walking can elicit similar effects.</p> Methods <p>Eleven healthy active males (age: 26 ± 2&#xa0;yr; BMI: 22.8 ± 2.6&#xa0;kg/m<sup>2</sup>) took part in a randomized and repeated-measures cross-over study with: (1) normal sleep (NS; 8&#xa0;h sleep opportunity); (2) sleep restriction (SR; 3&#xa0;h sleep opportunity); and (3) sleep restriction + exercise (SRE; 3&#xa0;h sleep opportunity followed by 30&#xa0;min brisk walking at 50%V̇O<sub>2max</sub>). This was followed by a 2-h 75&#xa0;g oral glucose tolerance test (OGTT), with plasma samples collected at baseline, immediately post-exercise (or sedentary), and at regular intervals during OGTT.</p> Results <p>Total glucose area under the curve (tAUC) was lower in NS trial (924 [95%CI 865, 982] mmol/L) compared to both SR (1012 [95% CI 945, 1080] mmol/L, <i>p</i> = 0.018) and SRE trials (1006 [933, 1080] mmol/L, <i>p</i> = 0.002) and there was no difference between SR and SRE (<i>p</i> = 1.00). Insulin tAUC did not differ between trials (<i>p</i> = 0.472). There were no differences in fasting cortisol, c-reactive protein, and non-esterified fatty acids, and fasting and postprandial triacylglycerols, cholesterol, aspartate aminotransferase, and alanine aminotransferase concentrations between trials (all, <i>p</i> &gt; 0.05).</p> Conclusion <p>In healthy physically active young males, a single night of partial sleep restriction results in a decrease in glucose tolerance during a 2-h OGTT performed the following morning and this impaired response is not rescued by 30&#xa0;min of brisk walking immediately prior to the OGTT.</p>

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Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月21日

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  • Che-Wei Hsu,
  • Chieh-Sheng Tseng,
  • Richard S. Metcalfe,
  • Yung-Chih Chen

摘要

Background

High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (e.g., glucose control) that is observed after a night of inadequate sleep. It is unknown whether moderate-intensity walking can elicit similar effects.

Methods

Eleven healthy active males (age: 26 ± 2 yr; BMI: 22.8 ± 2.6 kg/m2) took part in a randomized and repeated-measures cross-over study with: (1) normal sleep (NS; 8 h sleep opportunity); (2) sleep restriction (SR; 3 h sleep opportunity); and (3) sleep restriction + exercise (SRE; 3 h sleep opportunity followed by 30 min brisk walking at 50%V̇O2max). This was followed by a 2-h 75 g oral glucose tolerance test (OGTT), with plasma samples collected at baseline, immediately post-exercise (or sedentary), and at regular intervals during OGTT.

Results

Total glucose area under the curve (tAUC) was lower in NS trial (924 [95%CI 865, 982] mmol/L) compared to both SR (1012 [95% CI 945, 1080] mmol/L, p = 0.018) and SRE trials (1006 [933, 1080] mmol/L, p = 0.002) and there was no difference between SR and SRE (p = 1.00). Insulin tAUC did not differ between trials (p = 0.472). There were no differences in fasting cortisol, c-reactive protein, and non-esterified fatty acids, and fasting and postprandial triacylglycerols, cholesterol, aspartate aminotransferase, and alanine aminotransferase concentrations between trials (all, p > 0.05).

Conclusion

In healthy physically active young males, a single night of partial sleep restriction results in a decrease in glucose tolerance during a 2-h OGTT performed the following morning and this impaired response is not rescued by 30 min of brisk walking immediately prior to the OGTT.