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<p>The purpose of this study was to compare the response of cytokines, and adipokines to high-intensity interval running (HIIR) versus cycling (HIIC) in female adolescents. Eleven untrained adolescent females at post-peak height velocity, aged 15–19&#xa0;years, performed two trials (HIIR and HIIC) in a randomised order. Each participant performed a progressive incremental test for each mode of exercise to determine the &gt; 90% max workload for the trials. The trials consisted of 8 bouts of 1&#xa0;min of running or cycling at &gt; 90% maximal workload with 1&#xa0;min of passive recovery in between bouts. Blood samples were collected pre-exercise, 5- and 60-min post-exercise. Pro-inflammatory TNF-α, anti-inflammatory IL-10, IL-6 (pro-/anti-inflammatory), leptin and adiponectin were measured in serum. IL-6 increased at 5&#xa0;min (time-effect: <i>β</i> = 0.656 ± −&#xa0;0.277, <i>p</i> = 0.032) and 60&#xa0;min following exercise compared to pre-exercise (time-effect: <i>β</i> = 1.036 ± 0.277, <i>p</i> = 0.001) in both trials. IL-10 started to increase immediately after exercise (time effect: <i>β</i> = 0.170 ± 0.069, <i>p</i> = 0.025) and peaked 60&#xa0;min after exercise compared to pre-exercise (time effect: <i>β</i> = 0.317 ± 0.069, <i>p</i> &lt; 0.001). TNF-α concentrations peaked 5&#xa0;min only after HIIR (interaction effect: <i>β</i> = 2.777, <i>p</i> &lt; 0.001). No change was observed in the IL-6/IL-10 ratio, but a significant decrease was observed in the TNF-α/IL-10 ratio 60&#xa0;min post-exercise (time effect: <i>β</i> = −&#xa0;0.269 ± 0.070, <i>p</i> = 0.001). Leptin decreased 60&#xa0;min post-exercise compared to pre-exercise in both modes (time-effect: <i>β</i> = 0.155 ± 0.505, <i>p</i> = 0.004). No change was observed in adiponectin and the adiponectin/leptin ratio. In female adolescents, high-intensity interval exercise induces an immediate, transient pro-inflammatory response accompanied by a delayed increase in anti-inflammatory cytokines and leptin, irrespective of exercise mode.</p>

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Cytokine and adipokine response following high-intensity interval running and cycling in female adolescents

  • 期刊论文

  • 发表日期：

    2025年6月19日

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  • Pedro H. Narciso,
  • Ana E. von Ah Morano,
  • Ricardo R. Agostinete,
  • André O. Werneck,
  • Anthony J. Giannopoulos,
  • Madison Bell,
  • Bárbara M. Antunes,
  • Fabio S. Lira,
  • Rômulo A. Fernandes,
  • Panagiota Klentrou

摘要

The purpose of this study was to compare the response of cytokines, and adipokines to high-intensity interval running (HIIR) versus cycling (HIIC) in female adolescents. Eleven untrained adolescent females at post-peak height velocity, aged 15–19 years, performed two trials (HIIR and HIIC) in a randomised order. Each participant performed a progressive incremental test for each mode of exercise to determine the > 90% max workload for the trials. The trials consisted of 8 bouts of 1 min of running or cycling at > 90% maximal workload with 1 min of passive recovery in between bouts. Blood samples were collected pre-exercise, 5- and 60-min post-exercise. Pro-inflammatory TNF-α, anti-inflammatory IL-10, IL-6 (pro-/anti-inflammatory), leptin and adiponectin were measured in serum. IL-6 increased at 5 min (time-effect: β = 0.656 ± − 0.277, p = 0.032) and 60 min following exercise compared to pre-exercise (time-effect: β = 1.036 ± 0.277, p = 0.001) in both trials. IL-10 started to increase immediately after exercise (time effect: β = 0.170 ± 0.069, p = 0.025) and peaked 60 min after exercise compared to pre-exercise (time effect: β = 0.317 ± 0.069, p < 0.001). TNF-α concentrations peaked 5 min only after HIIR (interaction effect: β = 2.777, p < 0.001). No change was observed in the IL-6/IL-10 ratio, but a significant decrease was observed in the TNF-α/IL-10 ratio 60 min post-exercise (time effect: β = − 0.269 ± 0.070, p = 0.001). Leptin decreased 60 min post-exercise compared to pre-exercise in both modes (time-effect: β = 0.155 ± 0.505, p = 0.004). No change was observed in adiponectin and the adiponectin/leptin ratio. In female adolescents, high-intensity interval exercise induces an immediate, transient pro-inflammatory response accompanied by a delayed increase in anti-inflammatory cytokines and leptin, irrespective of exercise mode.