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Purpose <p>Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance.</p> Methods <p>Fifteen males (age: 27 ± 5&#xa0;y; BMI: 24.1 ± 3.8&#xa0;kg/m<sup>2</sup>) completed two randomised trials, involving consuming either 40&#xa0;mL/kg body mass water to maintain euhydration (EU) or severe fluid restriction via limiting water consumption to 100&#xa0;mL (HYP). A standardised dry food diet was consumed in both trials (~ 300&#xa0;g water). At baseline and 24&#xa0;h post-baseline, nude body mass, and blood and urine samples (additional urine sample at 12&#xa0;h) were collected. An oral glucose tolerance test was conducted after 24-h post-baseline measurements (<i>n</i> = 12).</p> Results <p>At 24&#xa0;h, body mass loss (HYP: −&#xa0;1.52 ± 0.34%, EU: −&#xa0;0.24 ± 0.40%), plasma volume loss, serum, and urine osmolality were greater in HYP than EU (<i>P</i> ≤ 0.004). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were greater in HYP at 12 (HYP: 1.097 ± 0.587&#xa0;ng/mOsm, EU: 0.570 ± 0.408&#xa0;ng/mOsm; <i>P</i> &lt; 0.001) and 24-h (HYP: 1.932 ± 1.173&#xa0;ng/mOsm, EU: 1.599 ± 1.012&#xa0;ng/mOsm; <i>P</i> = 0.01). There was no trial-by-time interactions for osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (<i>P</i> = 0.781) or plasma glucose (<i>P</i> = 0.550) and insulin (<i>P</i> = 0.193) concentrations.</p> Conclusion <p>Hypohydration produced by 24-h fluid restriction increased proximal tubular injury but did not affect glucose tolerance.</p>

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24 h severe fluid restriction increases a biomarker of renal injury in healthy males

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月7日

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  • Loris A. Juett,
  • Mark P. Funnell,
  • Harriet A. Carroll,
  • Lewis J. James,
  • Stephen A. Mears

摘要

Purpose

Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance.

Methods

Fifteen males (age: 27 ± 5 y; BMI: 24.1 ± 3.8 kg/m2) completed two randomised trials, involving consuming either 40 mL/kg body mass water to maintain euhydration (EU) or severe fluid restriction via limiting water consumption to 100 mL (HYP). A standardised dry food diet was consumed in both trials (~ 300 g water). At baseline and 24 h post-baseline, nude body mass, and blood and urine samples (additional urine sample at 12 h) were collected. An oral glucose tolerance test was conducted after 24-h post-baseline measurements (n = 12).

Results

At 24 h, body mass loss (HYP: − 1.52 ± 0.34%, EU: − 0.24 ± 0.40%), plasma volume loss, serum, and urine osmolality were greater in HYP than EU (P ≤ 0.004). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were greater in HYP at 12 (HYP: 1.097 ± 0.587 ng/mOsm, EU: 0.570 ± 0.408 ng/mOsm; P < 0.001) and 24-h (HYP: 1.932 ± 1.173 ng/mOsm, EU: 1.599 ± 1.012 ng/mOsm; P = 0.01). There was no trial-by-time interactions for osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (P = 0.781) or plasma glucose (P = 0.550) and insulin (P = 0.193) concentrations.

Conclusion

Hypohydration produced by 24-h fluid restriction increased proximal tubular injury but did not affect glucose tolerance.