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<p>Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. As part of the intercellular communication system, they regulate signaling pathways significant for animal development including Wnt and BMP. This review summarizes the current knowledge of SFRP functions, focusing on recent discoveries that offer new insights into the role of interactions between SFRPs and Wnt signaling pathways in morphogenesis.</p>

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Secreted Frizzled-related proteins in animal development

  • 期刊论文

  • 发表日期：

    2025年8月15日

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  • Konstantin Sadriev

摘要

Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. As part of the intercellular communication system, they regulate signaling pathways significant for animal development including Wnt and BMP. This review summarizes the current knowledge of SFRP functions, focusing on recent discoveries that offer new insights into the role of interactions between SFRPs and Wnt signaling pathways in morphogenesis.