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<p>Intracellularly expressed integrin associated proteins (IAPs) play pivotal role in facilitating cellular adhesion and survival. The integrin linked kinase (ILK)–PINCH–parvin (IPP) complex regulates cell–matrix interactions crucial for tissue development and homeostasis by functioning as an adapter between integrin and actin cytoskeleton. This review provides a compiled structural and functional insight into the IPP complex and its interacting partners, highlighting its conservation and signalling pathway, addressing a cross-talk across its homologues. Finally, the study sheds light on the association of the complex members with biological processes and disease progression, thus potentiating further exploration of the IPP complex within the integrin signalling pathway.</p>

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The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Ushashi Ain,
  • Benazir Fatma,
  • Hena Firdaus

摘要

Intracellularly expressed integrin associated proteins (IAPs) play pivotal role in facilitating cellular adhesion and survival. The integrin linked kinase (ILK)–PINCH–parvin (IPP) complex regulates cell–matrix interactions crucial for tissue development and homeostasis by functioning as an adapter between integrin and actin cytoskeleton. This review provides a compiled structural and functional insight into the IPP complex and its interacting partners, highlighting its conservation and signalling pathway, addressing a cross-talk across its homologues. Finally, the study sheds light on the association of the complex members with biological processes and disease progression, thus potentiating further exploration of the IPP complex within the integrin signalling pathway.