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Purpose <p>To assess the correlation between photoreceptor mosaic integrity in chronic central serous chorioretinopathy (cCSCR) and multiple morpho-functional parameters, including photoreceptor density (PD), normalized reflectivity of photoreceptor layers (NR-PRL), normalized reflectivity of the retinal pigment epithelium (NR-RPE), choriocapillaris vascular perfusion density (CC-VPD), and retinal sensitivity (RS).</p> Methods <p>This observational cross-sectional study was conducted between June 2023 and September 2024. Patients with cCSCR and healthy controls underwent imaging with Spectralis High Magnification Module (HMM), structural OCT, and OCT-Angiography in the macular area. Regions of interest were selected and topographically superimposed across modalities. Retinal sensitivity was assessed using fundus microperimetry with a 4-2-1 automated staircase strategy.</p> Results <p>Mean photoreceptor density was significantly lower in cCSCR eyes than in healthy controls (6617.8 vs. 11162.3 cells/mm², <i>p</i> = 0.0004). Mean NR-PRL was 0.6 in cCSCR and 0.9 in controls (<i>p</i> = 0.0074), while NR-RPE was also significantly reduced in cCSCR (<i>p</i> = 0.0465). Mean CC-VPD was 41.8% in cCSCR compared with 63.7% in controls (<i>p</i> = 0.0011). Mean retinal sensitivity was significantly decreased in cCSCR (10.74 ± 3.90 dB) versus controls (19.39 ± 3.90 dB; <i>p</i> = 0.0001) and strongly correlated with photoreceptor density. A strong correlation between NR-PRL and NR-RPE was observed in both controls (<i>r</i> = 0.883, <i>p</i> = 0.014) and cCSCR eyes (<i>r</i> = 0.884, <i>p</i> = 0.015).</p> Conclusions <p>Photoreceptor mosaic integrity significantly correlates with retinal sensitivity in cCSCR. HMM represents a reliable and accessible in vivo tool for quantifying photoreceptor loss and its functional impact.</p>

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Photoreceptors integrity as surrogate of retinal sensitivity in chronic central serous chorioretinopathy: a multimodal imaging study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月31日

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  • Marco Lupidi,
  • Alessio Muzi,
  • Giulia Gregori,
  • Daniela Fruttini,
  • Lorenzo Mangoni,
  • Felice Cardillo Piccolino,
  • Clara Rizzo,
  • Jay Chhablani,
  • Cesare Mariotti

摘要

Purpose

To assess the correlation between photoreceptor mosaic integrity in chronic central serous chorioretinopathy (cCSCR) and multiple morpho-functional parameters, including photoreceptor density (PD), normalized reflectivity of photoreceptor layers (NR-PRL), normalized reflectivity of the retinal pigment epithelium (NR-RPE), choriocapillaris vascular perfusion density (CC-VPD), and retinal sensitivity (RS).

Methods

This observational cross-sectional study was conducted between June 2023 and September 2024. Patients with cCSCR and healthy controls underwent imaging with Spectralis High Magnification Module (HMM), structural OCT, and OCT-Angiography in the macular area. Regions of interest were selected and topographically superimposed across modalities. Retinal sensitivity was assessed using fundus microperimetry with a 4-2-1 automated staircase strategy.

Results

Mean photoreceptor density was significantly lower in cCSCR eyes than in healthy controls (6617.8 vs. 11162.3 cells/mm², p = 0.0004). Mean NR-PRL was 0.6 in cCSCR and 0.9 in controls (p = 0.0074), while NR-RPE was also significantly reduced in cCSCR (p = 0.0465). Mean CC-VPD was 41.8% in cCSCR compared with 63.7% in controls (p = 0.0011). Mean retinal sensitivity was significantly decreased in cCSCR (10.74 ± 3.90 dB) versus controls (19.39 ± 3.90 dB; p = 0.0001) and strongly correlated with photoreceptor density. A strong correlation between NR-PRL and NR-RPE was observed in both controls (r = 0.883, p = 0.014) and cCSCR eyes (r = 0.884, p = 0.015).

Conclusions

Photoreceptor mosaic integrity significantly correlates with retinal sensitivity in cCSCR. HMM represents a reliable and accessible in vivo tool for quantifying photoreceptor loss and its functional impact.