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Purpose <p>To investigate the effects of autologous platelet-rich plasma (PRP) application on recurrent or refractory full-thickness macular hole (FTMH) in patients who had undergone vitrectomy and internal limiting membrane (ILM) peeling.</p> Methods <p>Databases including PubMed, EMBASE, and Cochrane Library were searched on April 10, 2025. Studies that investigated the effects of autologous PRP or whole blood application to treat recurrent or refractory FTMH were included. The primary outcome was the closure rate with the procedure, and a meta-analysis of proportions was performed to estimate pooled closure rates.</p> Results <p>Among preliminary identification of 222 studies, 10 case series using autologous PRP only and three studies using autologous PRP/whole blood and additional flap or graft (retina, lens capsule, amniotic membrane, or residual ILM) were included in the meta-analysis. The overall pooled closure rate with autologous PRP application was 85% (95 confidence interval [CI]: 75–93%), while the additional use of a flap or graft led to an 87% closure rate (95% CI: 64–100%) in cases presenting with recurrent or refractory FTMH. There were no significant differences in closure rate of recurrent or refractory FTMH between groups (<i>p</i> = 0.820). No adverse effects were reported regarding the use of autologous PRP or whole blood application.</p> Conclusion <p>The use of autologous PRP with or without additional flaps was as effective to achieve anatomical closure of recurrent or refractory FTMH, without the need for the concurrent flap or graft techniques.</p>

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Role of autologous platelet-rich plasma for recurrent or refractory macular hole in the era of various flap techniques: a meta-analysis

  • 期刊论文

  • 发表日期：

    2026年4月18日

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  • Chungwoon Kim,
  • Kyung Ho Lee,
  • Eunzee Lee,
  • Suji Yeo,
  • Ji Hun Song,
  • Hae Rang Kim,
  • Yoo-Ri Chung

摘要

Purpose

To investigate the effects of autologous platelet-rich plasma (PRP) application on recurrent or refractory full-thickness macular hole (FTMH) in patients who had undergone vitrectomy and internal limiting membrane (ILM) peeling.

Methods

Databases including PubMed, EMBASE, and Cochrane Library were searched on April 10, 2025. Studies that investigated the effects of autologous PRP or whole blood application to treat recurrent or refractory FTMH were included. The primary outcome was the closure rate with the procedure, and a meta-analysis of proportions was performed to estimate pooled closure rates.

Results

Among preliminary identification of 222 studies, 10 case series using autologous PRP only and three studies using autologous PRP/whole blood and additional flap or graft (retina, lens capsule, amniotic membrane, or residual ILM) were included in the meta-analysis. The overall pooled closure rate with autologous PRP application was 85% (95 confidence interval [CI]: 75–93%), while the additional use of a flap or graft led to an 87% closure rate (95% CI: 64–100%) in cases presenting with recurrent or refractory FTMH. There were no significant differences in closure rate of recurrent or refractory FTMH between groups (p = 0.820). No adverse effects were reported regarding the use of autologous PRP or whole blood application.

Conclusion

The use of autologous PRP with or without additional flaps was as effective to achieve anatomical closure of recurrent or refractory FTMH, without the need for the concurrent flap or graft techniques.