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Purpose <p>This study aimed to quantitatively analyze the changes in trabecular meshwork pigment after implantable collamer lens (ICL) implantation and its effect on intraocular pressure (IOP), and to analyze the influencing factors of trabecular meshwork pigment changes.</p> Methods <p>A total of 80 patients with moderate to high myopia who underwent ICL implantation were monitored for a minimum of 6&#xa0;months post-operation. Pre- and post-operatively, the temporal, nasal, superior, and inferior trabecular meshwork areas were evaluated using gonioscopy and photographed. ImageJ software was used to calculate the average grayscale value of TM pigment. Anterior segment OCT and ultrasound biomicroscopy (UBM) was utilized to measure the TIA, vault and iris-ICL contact distance.</p> Results <p>The total TM average gray value decreased by 13.6% (<i>P</i> &lt; 0.001) at 1&#xa0;month postoperatively compared to the preoperative measurement. By 3&#xa0;months postoperatively, the total TM gray value had increased by 7.4% (<i>P</i> &lt; 0.001) compared to 1&#xa0;month postoperatively. At 6&#xa0;months postoperatively, there was no statistically significant difference (<i>P</i> = 0.063) compared to the 3-month value. There was no correlation between the total average ΔTM grayscale values of the four quadrants and ΔIOP1m (R<sup>2</sup> = 0.005, <i>P</i> = 0.316). ΔTM<sub>1m</sub> grayscale values and ΔILCD<sub>1m</sub> revealed no correlation. ΔTM<sub>1m</sub> grayscale value is weakly positively correlated with ICL size (standardized coefficient = 0.027, <i>P</i> = 0.043).ΔTM<sub>6m</sub> grayscale value is positively correlated with white-to-white (standardized coefficient = 0.242, <i>P</i> = 0.008).</p> Conclusion <p>Quantitative analysis revealed a transient increase in TM pigment levels in all quadrants after ICL implantation. The increase in TM pigment deposition did not impact IOP.</p>

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Quantitative analysis of trabecular meshwork pigment after ICL implantation and influencing factors

  • 期刊论文

  • 发表日期：

    2026年4月11日

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  • Jing Yang,
  • Hao Wang,
  • Yanhui Bai,
  • Xiaohang Jiao,
  • Weiqun Wang

摘要

Purpose

This study aimed to quantitatively analyze the changes in trabecular meshwork pigment after implantable collamer lens (ICL) implantation and its effect on intraocular pressure (IOP), and to analyze the influencing factors of trabecular meshwork pigment changes.

Methods

A total of 80 patients with moderate to high myopia who underwent ICL implantation were monitored for a minimum of 6 months post-operation. Pre- and post-operatively, the temporal, nasal, superior, and inferior trabecular meshwork areas were evaluated using gonioscopy and photographed. ImageJ software was used to calculate the average grayscale value of TM pigment. Anterior segment OCT and ultrasound biomicroscopy (UBM) was utilized to measure the TIA, vault and iris-ICL contact distance.

Results

The total TM average gray value decreased by 13.6% (P < 0.001) at 1 month postoperatively compared to the preoperative measurement. By 3 months postoperatively, the total TM gray value had increased by 7.4% (P < 0.001) compared to 1 month postoperatively. At 6 months postoperatively, there was no statistically significant difference (P = 0.063) compared to the 3-month value. There was no correlation between the total average ΔTM grayscale values of the four quadrants and ΔIOP1m (R2 = 0.005, P = 0.316). ΔTM1m grayscale values and ΔILCD1m revealed no correlation. ΔTM1m grayscale value is weakly positively correlated with ICL size (standardized coefficient = 0.027, P = 0.043).ΔTM6m grayscale value is positively correlated with white-to-white (standardized coefficient = 0.242, P = 0.008).

Conclusion

Quantitative analysis revealed a transient increase in TM pigment levels in all quadrants after ICL implantation. The increase in TM pigment deposition did not impact IOP.