Scholarlink

Purpose <p>To investigate the association between intracystic hyperreflectivity (ICH) observed in macular optical cohorence tomography (OCT) and aqueous cytokine levels in patients with diabetic macular edema (DME), and to evaluate the impact of cataract surgery and intravitreal agents on these parameters.</p> Methods <p>This prospective, open-label observational study included DME patients undergoing cataract surgery with simultaneous intravitreal injection. Based on prior treatment history, patients were assigned to either the aflibercept or dexamethasone groups. Aqueous humor samples were collected during surgery for cytokine analysis. ICH in macular OCT was measured on postoperative day 1 and month 1 using ImageJ software. Correlations between ICH and cytokine levels, as well as longitudinal changes based on injection type and OCT biomarkers, were analyzed.</p> Results <p>Fifty-six patients (28 per group) were included. Significant correlations were found between ICH and IL-1β, IL-6, IL-8, and IL-10 (<i>p</i> = 0.039, <i>R</i> = 0.277; <i>p</i> = 0.003, <i>R</i> = 0.395; <i>p</i> &lt; 0.001, <i>R</i> = 0.506; <i>p</i> = 0.049, <i>R</i> = 0.265). ICH also correlated with OCT biomarkers and increased after surgery, with a less pronounced rise in the dexamethasone group (<i>p</i> &lt; 0.001; <i>p</i> = 0.013; <i>p</i> = 0.145).</p> Conclusion <p>ICH is strongly associated with intraocular inflammatory cytokines and may serve as a potential OCT-based biomarker of inflammation in DME.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The correlation between intracystic reflectivity and intraocular inflammation in diabetic macular edema: a novel inflammatory biomarker

  • 期刊论文

  • 发表日期：

    2026年1月3日

查看全文
  • Tahsin Uzundede,
  • Akın Çakır,
  • Eren Vurgun,
  • Gamze Karataş,
  • Hasan B. Velioğlu,
  • Dilan Yıldız,
  • Sezin D. Çakır,
  • Mustafa N. Elçioğlu

摘要

Purpose

To investigate the association between intracystic hyperreflectivity (ICH) observed in macular optical cohorence tomography (OCT) and aqueous cytokine levels in patients with diabetic macular edema (DME), and to evaluate the impact of cataract surgery and intravitreal agents on these parameters.

Methods

This prospective, open-label observational study included DME patients undergoing cataract surgery with simultaneous intravitreal injection. Based on prior treatment history, patients were assigned to either the aflibercept or dexamethasone groups. Aqueous humor samples were collected during surgery for cytokine analysis. ICH in macular OCT was measured on postoperative day 1 and month 1 using ImageJ software. Correlations between ICH and cytokine levels, as well as longitudinal changes based on injection type and OCT biomarkers, were analyzed.

Results

Fifty-six patients (28 per group) were included. Significant correlations were found between ICH and IL-1β, IL-6, IL-8, and IL-10 (p = 0.039, R = 0.277; p = 0.003, R = 0.395; p < 0.001, R = 0.506; p = 0.049, R = 0.265). ICH also correlated with OCT biomarkers and increased after surgery, with a less pronounced rise in the dexamethasone group (p < 0.001; p = 0.013; p = 0.145).

Conclusion

ICH is strongly associated with intraocular inflammatory cytokines and may serve as a potential OCT-based biomarker of inflammation in DME.