Scholarlink

Introduction <p>We report a case series of pediatric patients with incidentally discovered atypical maculopathy, namely, benign foveal depigmentation of the retinal pigment epithelium (BFD). Longitudinal data, both functional and morphological, were analyzed.</p> Materials and methods <p>Functional tests (perimetry, full-field, multifocal and pattern ERG) were performed using the Mon PackOne® unit (Métrovision, Pérenchies, France), and multimodal retinal imaging was carried out using the Heidelberg Retinal Tomograph 2 and Heidelberg Spectralis SD-OCT (Heidelberg Inc., Germany).</p> Results <p>Four patients were examined, two of whom were followed longitudinally. Pattern ERG, multifocal ERG, and central static perimetry were all within normal limits. The reflective structure of the retinal layers in the foveolar zone appeared normal on SD-OCT, except for a cone of choroidal hyperreflectivity corresponding to the lesion site. The lesion was more evident on near-infrared autofluorescence imaging, presenting as a well-defined, round, hypoautofluorescent foveal area. No progression was observed in the two patients for whom follow-up data were available.</p> Conclusion <p>BFD is a rare and sporadic condition that may affect both adults and children. It has no functional visual impact. However, long-term follow-up is advisable to confirm the benign and non-progressive nature of these depigmented macular lesions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Benign foveal retinal pigment epithelium hypopigmentation without functional loss : pediatric case series

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月10日

查看全文
  • Emilie Boulert,
  • Isabelle Drumare,
  • Claire-Marie Dhaenens,
  • Sabine Defoort-Dhellemmes,
  • Vasily Smirnov

摘要

Introduction

We report a case series of pediatric patients with incidentally discovered atypical maculopathy, namely, benign foveal depigmentation of the retinal pigment epithelium (BFD). Longitudinal data, both functional and morphological, were analyzed.

Materials and methods

Functional tests (perimetry, full-field, multifocal and pattern ERG) were performed using the Mon PackOne® unit (Métrovision, Pérenchies, France), and multimodal retinal imaging was carried out using the Heidelberg Retinal Tomograph 2 and Heidelberg Spectralis SD-OCT (Heidelberg Inc., Germany).

Results

Four patients were examined, two of whom were followed longitudinally. Pattern ERG, multifocal ERG, and central static perimetry were all within normal limits. The reflective structure of the retinal layers in the foveolar zone appeared normal on SD-OCT, except for a cone of choroidal hyperreflectivity corresponding to the lesion site. The lesion was more evident on near-infrared autofluorescence imaging, presenting as a well-defined, round, hypoautofluorescent foveal area. No progression was observed in the two patients for whom follow-up data were available.

Conclusion

BFD is a rare and sporadic condition that may affect both adults and children. It has no functional visual impact. However, long-term follow-up is advisable to confirm the benign and non-progressive nature of these depigmented macular lesions.