Purpose <p>Review Pattern Electroretinogram (PERG) data from a pediatric population to characterize the development of response.</p> Methods <p>A case review of 104 subjects who had PERG aged between 0 and 9 years of age as part of routine clinical testing who were categorized as normal. PERG responses were recorded with skin electrodes, with the stimulus presented on a 40^o screen. The main outcome measures were the amplitude and timing of the main components of the PERG, the P50 and N95.</p> Results <p>An increase in P50 amplitude was noted over the first 2 years of life, a less rapid increase in amplitude was observed after this. The P50 timing was noted to decrease in the first 6 months but stabilized after this. A similar increase in amplitude was observed for the N95 amplitude with a modest decrease in latency.</p> Conclusion <p>This study has shown an increase in PERG amplitude beyond the first 6 months of life with the most rapid rate of increase of response occurring in the first 2 years. This physiological data potentially documents the functional maturation of the human macula that parallels the anatomical changes noted via histology.</p> Key messages <p>Robust PERG responses are possible in pediatric cases recorded with skin electrode to widefield stimuli, even in young infants.</p> <p>Paper provides evidence of physiological development of macula that correlates well with previously documented anatomical maturation.</p>