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Purpose <p>To report the efficacy and safety of twice daily 0.02% Chlorhexidine in treating chronic refractory blepharoconjunctivitis.</p> Methods <p>A case series of 10 patients with symptomatic, chronic, and resistant-to-treatment bilateral blepharoconjunctivitis were referred to our clinic. Conjunctival swab cultures were obtained, anterior segment photographs were taken, and all patients began treatment with 0.02% chlorhexidine administered twice daily. Clinical signs and symptoms were monitored over the follow-up period.</p> Results <p>Of ten patients (20 eyes, mean age was 67.6 +/- 19.05 years), 6/10 had positive cultures of a resistant strain of Staphylococcus aureus or epidermidis previously treated with topical antibiotic drops. All patients showed complete resolution of conjunctival hyperemia and reported substantial improvement of symptoms after 2 weeks of treatment. At 1-month follow-up, the patients reported complete resolution of symptoms. Best corrected visual acuity (BCVA) before and after treatment differences were not statistically significant.</p> Conclusion <p>Twice-daily application of 0.02% chlorhexidine appears to be a safe and effective treatment for patients with chronic, treatment-resistant blepharoconjunctivitis, offering significant symptomatic relief and clinical improvement.</p>

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Chlorhexidine 0.02% treatment for refractory blepharoconjunctivitis

  • 期刊论文

  • 发表日期：

    2025年11月7日

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  • Eran Greenbaum,
  • Arie Nemet,
  • Fani Segev,
  • Asaf Friehmann

摘要

Purpose

To report the efficacy and safety of twice daily 0.02% Chlorhexidine in treating chronic refractory blepharoconjunctivitis.

Methods

A case series of 10 patients with symptomatic, chronic, and resistant-to-treatment bilateral blepharoconjunctivitis were referred to our clinic. Conjunctival swab cultures were obtained, anterior segment photographs were taken, and all patients began treatment with 0.02% chlorhexidine administered twice daily. Clinical signs and symptoms were monitored over the follow-up period.

Results

Of ten patients (20 eyes, mean age was 67.6 +/- 19.05 years), 6/10 had positive cultures of a resistant strain of Staphylococcus aureus or epidermidis previously treated with topical antibiotic drops. All patients showed complete resolution of conjunctival hyperemia and reported substantial improvement of symptoms after 2 weeks of treatment. At 1-month follow-up, the patients reported complete resolution of symptoms. Best corrected visual acuity (BCVA) before and after treatment differences were not statistically significant.

Conclusion

Twice-daily application of 0.02% chlorhexidine appears to be a safe and effective treatment for patients with chronic, treatment-resistant blepharoconjunctivitis, offering significant symptomatic relief and clinical improvement.