Background <p>Spinal cord injuries and disorders (SCI/D) have been reported by some studies to correlate with increased risk of ischemic cerebral stroke. However, the reports are sparse, conflicting, generally lacked SCI/D-specific analysis, and commonly had small sample sizes.</p> Objective <p>To determine whether SCI/D are a risk factor for ischemic stroke and evaluate for underlying SCI/D-related stroke risk correlations.</p> Methods <p>Using a retrospective design aimed to capture a large sample with SCI/D, first-ever stroke incidence was estimated by Poisson regression models for US Veterans with and without SCI/D during fiscal years 2017–2021 using US Veterans Health Administration and Medicare utilization data. Models were adjusted for Veteran characteristics, common stroke risk factors, and prescriptions for stroke–prophylactic medications.</p> Results <p>Analyses included 560,314 Veterans, including 12,450 with SCI/D. Adjusting for person-days, age, sex, smoking, diabetes, hypertension, atrial fibrillation, race, ethnicity, and stroke–prophylactic medications, Veterans with SCI/D had a 19% higher stroke incidence compared to controls [incidence rate ratio (IRR) 1.19, 95%CI: 1.11–1.28]. Compared to controls, stroke incidence was 50% and 31% higher with high and low tetraplegia, respectively [IRR 1.50, 95%CI: 1.17–1.92 and IRR 1.31, 95%CI: 1.02–1.67], and markedly higher for younger Veterans with SCI/D (ages &lt; 40&#xa0;years) [IRR 2.25, 95%CI: 1.24–4.08]. Relative to controls, stroke incidence was 36% higher with non-traumatic SCI/D [IRR 1.36, 95%CI: 1.24–1.49], but not with traumatic spinal cord injury [IRR 1.05, 95%CI: 0.95–1.17].</p> Conclusion <p>SCI/D are a risk factor for ischemic stroke in US Veterans, especially for Veterans with tetraplegia, non-traumatic SCI/D, and younger age.</p>