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Background <p>Cognitive impairment affects up to 70% of people with multiple sclerosis (PwMS), mainly impacting memory, processing speed and attention. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is widely used to monitor these deficits and has two parallel versions, A and B, to minimize practice effects. The Italian norms for version B have been published years ago and may not reflect current demographic trends.</p> Objectives <p>To revise and update normative data for the BRB-N version B in the Italian population and to harmonize these procedures with those used for other neuropsychological batteries used in MS.</p> Methods <p>We recruited 224 healthy subjects (94 males, 130 females; mean age = 43.34, standard deviation [SD] = 14.41, range: 19–86&#xa0;years; mean education = 13.89, SD = 4.05, range = 5–23) from two centers (Milan, Florence). Each raw BRB-N version B score was transformed into a scaled‐score metric, then regressed on centered age, centered age<sup>2</sup>, education, and sex.</p> Results <p>No significant differences were found in age and sex distribution between centers (all <i>p</i> ≥ 0.87), whereas Milan subjects showed a higher education compared to Florence subjects (<i>p</i> &lt; 0.001). Age and education emerged as consistent predictors across nearly all tests, while sex showed only limited influence. Regression analysis provided normative data to calculate demographically adjusted <i>z</i> scores for each BRB-N version B test. Despite differing sample size and composition, regression coefficients mirrored those from BRB-N version A updated normative data.</p> Conclusions <p>These updated, regression‐based norms for BRB-N version B align with other major MS neuropsychological batteries in Italy, improving cognitive assessment accuracy in clinical and research settings.</p>

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The brief repeatable battery of neuropsychological test (BRB-N) version B: update of Italian normative data

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Nicolò Tedone,
  • Marta Grosselle,
  • Emilio Portaccio,
  • Maria Pia Amato,
  • Damiano Mistri,
  • Massimo Filippi,
  • Maria A. Rocca

摘要

Background

Cognitive impairment affects up to 70% of people with multiple sclerosis (PwMS), mainly impacting memory, processing speed and attention. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is widely used to monitor these deficits and has two parallel versions, A and B, to minimize practice effects. The Italian norms for version B have been published years ago and may not reflect current demographic trends.

Objectives

To revise and update normative data for the BRB-N version B in the Italian population and to harmonize these procedures with those used for other neuropsychological batteries used in MS.

Methods

We recruited 224 healthy subjects (94 males, 130 females; mean age = 43.34, standard deviation [SD] = 14.41, range: 19–86 years; mean education = 13.89, SD = 4.05, range = 5–23) from two centers (Milan, Florence). Each raw BRB-N version B score was transformed into a scaled‐score metric, then regressed on centered age, centered age2, education, and sex.

Results

No significant differences were found in age and sex distribution between centers (all p ≥ 0.87), whereas Milan subjects showed a higher education compared to Florence subjects (p < 0.001). Age and education emerged as consistent predictors across nearly all tests, while sex showed only limited influence. Regression analysis provided normative data to calculate demographically adjusted z scores for each BRB-N version B test. Despite differing sample size and composition, regression coefficients mirrored those from BRB-N version A updated normative data.

Conclusions

These updated, regression‐based norms for BRB-N version B align with other major MS neuropsychological batteries in Italy, improving cognitive assessment accuracy in clinical and research settings.