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Background <p>Married or long-term partnered patients with chronic diseases generally have better outcomes than unmarried patients, likely due to the potential for multifaceted support. However, the impact of marital status on multiple sclerosis (MS) radiographic disease burden is currently unknown.</p> Objective <p>To compare total white matter hyperintensity lesion volumes, periventricular lesion volumes, and whole brain and grey matter volumes in married and unmarried people with MS (PwMS).</p> Methods <p>We utilized multivariable linear regression to assess for differences in brain atrophy and lesion volumes between these two groups controlling for sex, MS disease duration in years, hypertension, history of smoking, alcohol consumption, history of depression and/or anxiety, and medication possession ratio (MPR).</p> Results <p>Married PwMS had significantly lower total lesion volumes (β =  − 6.3, 95% CI − 12.1 to − 0.5, <i>p</i> = 0.033), lower PV lesion volumes (β =  − 6.1, 95% CI − 11.7 to − 0.6, <i>p</i> = 0.030), higher normalized whole brain volumes (β = 38.3, 95% CI 6.0 to 70.7, <i>p</i> = 0.021), and higher normalized grey matter volumes (β = 20.9, 95% CI − 0.7 to 42.6, <i>p</i> = 0.058) than unmarried PwMS.</p> Conclusion <p>Being married may be associated with improved MS outcomes as evidenced by decreased radiographic MS disease burden.</p>

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Marriage is associated with decreased lesion volumes and less brain atrophy in people with multiple sclerosis

  • 期刊论文

  • 发表日期：

    2025年1月15日

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  • Alexandra Balshi,
  • John Dempsey,
  • Sachin Kumbar,
  • Grace Leunberger,
  • Ursela Baber,
  • Jacob A. Sloane

摘要

Background

Married or long-term partnered patients with chronic diseases generally have better outcomes than unmarried patients, likely due to the potential for multifaceted support. However, the impact of marital status on multiple sclerosis (MS) radiographic disease burden is currently unknown.

Objective

To compare total white matter hyperintensity lesion volumes, periventricular lesion volumes, and whole brain and grey matter volumes in married and unmarried people with MS (PwMS).

Methods

We utilized multivariable linear regression to assess for differences in brain atrophy and lesion volumes between these two groups controlling for sex, MS disease duration in years, hypertension, history of smoking, alcohol consumption, history of depression and/or anxiety, and medication possession ratio (MPR).

Results

Married PwMS had significantly lower total lesion volumes (β =  − 6.3, 95% CI − 12.1 to − 0.5, p = 0.033), lower PV lesion volumes (β =  − 6.1, 95% CI − 11.7 to − 0.6, p = 0.030), higher normalized whole brain volumes (β = 38.3, 95% CI 6.0 to 70.7, p = 0.021), and higher normalized grey matter volumes (β = 20.9, 95% CI − 0.7 to 42.6, p = 0.058) than unmarried PwMS.

Conclusion

Being married may be associated with improved MS outcomes as evidenced by decreased radiographic MS disease burden.