Scholarlink

<p>Y-chromosomal short tandem repeats (Y-STRs) play a critical role in forensic genetics, particularly for mixture deconvolution, patrilineal kinship analysis, and familial searching. Nevertheless, conventional Y-STR systems often exhibit limited resolution in differentiating distantly related individuals or populations that share similar paternal genetic backgrounds. To address this limitation, we evaluated an enhanced massively parallel sequencing (MPS) panel comprising 44 Y-STRs and 260 Y-chromosomal single nucleotide polymorphisms (SNPs). Although this panel was previously developed, its performance had not been systematically validated across diverse populations within China. In this study, we assessed its forensic utility for paternal lineage differentiation and biogeographic ancestry inference. The results showed that the panel exhibited robust performance, achieving a haplotype diversity of 0.9998 and a discrimination capacity of 0.9922—both outperforming most commercially available Y-STR kits. Population genetic analysis revealed that the Dongxiang ethnic group possessed a distinctive paternal genetic structure, likely shaped by admixture between Asian and European ancestral components, and was clearly distinguishable from reference populations including northern and southern Han Chinese and the Xishuangbanna Dai. These findings underscored the value of the customized MPS panel for forensic applications involving paternal lineage tracing and ancestry assignment in Chinese populations. However, we acknowledge that the reference populations included in this study remain limited, precluding definitive conclusions regarding the paternal genetic structure of the Dongxiang ethnic group. Further validations across additional ethnic minorities are therefore warranted.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A high-resolution Y-chromosomal panel for forensic paternal lineage tracing and anthropological insight: unraveling the genetic structure of the Dongxiang ethnic minority

  • 期刊论文

  • 发表日期：

    2026年4月20日

查看全文
  • Qiong Lan,
  • Meiming Cai,
  • Yifeng Lin,
  • Fanzhang Lei,
  • Ming Zhao,
  • Hongbing Yao,
  • Bofeng Zhu

摘要

Y-chromosomal short tandem repeats (Y-STRs) play a critical role in forensic genetics, particularly for mixture deconvolution, patrilineal kinship analysis, and familial searching. Nevertheless, conventional Y-STR systems often exhibit limited resolution in differentiating distantly related individuals or populations that share similar paternal genetic backgrounds. To address this limitation, we evaluated an enhanced massively parallel sequencing (MPS) panel comprising 44 Y-STRs and 260 Y-chromosomal single nucleotide polymorphisms (SNPs). Although this panel was previously developed, its performance had not been systematically validated across diverse populations within China. In this study, we assessed its forensic utility for paternal lineage differentiation and biogeographic ancestry inference. The results showed that the panel exhibited robust performance, achieving a haplotype diversity of 0.9998 and a discrimination capacity of 0.9922—both outperforming most commercially available Y-STR kits. Population genetic analysis revealed that the Dongxiang ethnic group possessed a distinctive paternal genetic structure, likely shaped by admixture between Asian and European ancestral components, and was clearly distinguishable from reference populations including northern and southern Han Chinese and the Xishuangbanna Dai. These findings underscored the value of the customized MPS panel for forensic applications involving paternal lineage tracing and ancestry assignment in Chinese populations. However, we acknowledge that the reference populations included in this study remain limited, precluding definitive conclusions regarding the paternal genetic structure of the Dongxiang ethnic group. Further validations across additional ethnic minorities are therefore warranted.