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<p>The two-parametric Avrami-Dobrzyński model, originally based on the condensed matter physics for phase transitions, was applied to the cumulative populational mammary cancer data of laboratory rats. The joint effect of parity, irradiation and BRCA1 mutation on breast cancer incidence was analysed. The study showed that the proposed model fits well with the data points, however, the values of parameters differ regarding the investigated group of animals. It was concluded that both model’s parameters, which relate to the dimension of carcinogenesis dynamics and the age distribution, are good candidates for cancer risk assessment regarding different risk factors.</p>

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Application of the Avrami-Dobrzyński model for mammary tumorigenesis in irradiated rats indicates new candidates for parametric cancer risk assessment

  • 期刊论文

  • 发表日期：

    2025年4月7日

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  • Julianna Krasowska,
  • Tatsuhiko Imaoka,
  • Krzysztof W. Fornalski

摘要

The two-parametric Avrami-Dobrzyński model, originally based on the condensed matter physics for phase transitions, was applied to the cumulative populational mammary cancer data of laboratory rats. The joint effect of parity, irradiation and BRCA1 mutation on breast cancer incidence was analysed. The study showed that the proposed model fits well with the data points, however, the values of parameters differ regarding the investigated group of animals. It was concluded that both model’s parameters, which relate to the dimension of carcinogenesis dynamics and the age distribution, are good candidates for cancer risk assessment regarding different risk factors.