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Introduction <p>A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily exposure to house dust mite over 10 consecutive days. This finding raises the question of which factors determine the methacholine response in vivo.</p> Methods <p>Herein, multiple linear regression analyses were used to determine which baseline physiological characteristics are associated with the methacholine response.</p> Results <p>Among the 10 baseline characteristics studied, and depending on how the methacholine response was monitored during a concentration–response, lung tissue compliance was the most commonly and robustly associated with the methacholine response. Inspiratory capacity was the second most frequently associated.</p> Conclusion <p>These results suggest that lung tissue compliance and inspiratory capacity may be two important determinants of the methacholine response in BALB/c and C57BL/6 mice with and without experimental asthma.</p>

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Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Sébastien Hecht,
  • Andrés Rojas-Ruiz,
  • Magali Boucher,
  • Cyndi Henry,
  • Jorge Soliz,
  • Ynuk Bossé

摘要

Introduction

A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily exposure to house dust mite over 10 consecutive days. This finding raises the question of which factors determine the methacholine response in vivo.

Methods

Herein, multiple linear regression analyses were used to determine which baseline physiological characteristics are associated with the methacholine response.

Results

Among the 10 baseline characteristics studied, and depending on how the methacholine response was monitored during a concentration–response, lung tissue compliance was the most commonly and robustly associated with the methacholine response. Inspiratory capacity was the second most frequently associated.

Conclusion

These results suggest that lung tissue compliance and inspiratory capacity may be two important determinants of the methacholine response in BALB/c and C57BL/6 mice with and without experimental asthma.