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Aim <p>This study examined the effects of two accelerated repetitive transcranial magnetic stimulation (rTMS) protocols in patients with major depressive disorder (MDD).</p> Methods <p>Twenty-two patients received accelerated high-frequency rTMS (HF-rTMS; 10&#xa0;Hz, left prefrontal cortex), and 18 received accelerated low-frequency rTMS (LF-rTMS; 1&#xa0;Hz, right prefrontal cortex). Each participant underwent 10 sessions over 2 consecutive days (5 sessions per day). Depression, anxiety, and sleep quality were assessed using the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and Pittsburgh Sleep Quality Index (PSQI), respectively. Clinical outcomes were evaluated at baseline and at 1&#xa0;day, 2 weeks, and 4 weeks after treatment.</p> Results <p>HAM-D scores significantly decreased from baseline after accelerated rTMS and remained improved over 4 weeks. Both HF-rTMS and LF-rTMS produced comparable early reductions in depression severity, with LF-rTMS showing a greater HAM-D reduction at 4 weeks. HAM-A and PSQI scores also improved at 2 and 4 weeks in both groups, with no significant between-group differences.</p> Conclusions <p>Both accelerated HF- and LF-rTMS protocols were associated with improvements in depressive, anxiety and sleep symptoms in patients with MDD, and LF-rTMS may confer more sustained antidepressant effects.</p>

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High- and low-frequency accelerated repetitive transcranial magnetic stimulation for major depressive disorder

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月30日

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  • Chaeyeon Yang,
  • Yun Ji Kim,
  • Jihye Ahn,
  • Sehyun Jeon,
  • Jooyoung Lee,
  • Su-Young Song,
  • Seog Ju Kim

摘要

Aim

This study examined the effects of two accelerated repetitive transcranial magnetic stimulation (rTMS) protocols in patients with major depressive disorder (MDD).

Methods

Twenty-two patients received accelerated high-frequency rTMS (HF-rTMS; 10 Hz, left prefrontal cortex), and 18 received accelerated low-frequency rTMS (LF-rTMS; 1 Hz, right prefrontal cortex). Each participant underwent 10 sessions over 2 consecutive days (5 sessions per day). Depression, anxiety, and sleep quality were assessed using the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and Pittsburgh Sleep Quality Index (PSQI), respectively. Clinical outcomes were evaluated at baseline and at 1 day, 2 weeks, and 4 weeks after treatment.

Results

HAM-D scores significantly decreased from baseline after accelerated rTMS and remained improved over 4 weeks. Both HF-rTMS and LF-rTMS produced comparable early reductions in depression severity, with LF-rTMS showing a greater HAM-D reduction at 4 weeks. HAM-A and PSQI scores also improved at 2 and 4 weeks in both groups, with no significant between-group differences.

Conclusions

Both accelerated HF- and LF-rTMS protocols were associated with improvements in depressive, anxiety and sleep symptoms in patients with MDD, and LF-rTMS may confer more sustained antidepressant effects.