Scholarlink

Objectives <p>The link between clusters of unhealthy lifestyle behaviors and the risk of young-onset dementia remains unclear. This study aimed to assess the impact of multiple unhealthy lifestyle behaviors on the risk of developing young-onset dementia, including all-cause dementia, Alzheimer’s disease, and vascular dementia.</p> Methods <p>We analyzed nationwide Korean National Health Insurance Service data from individuals aged 40–60 years who underwent health screening in 2009 and were followed until 2018 or age 65. The Unhealthy Lifestyle Behavior Score (ULBS) was derived from smoking, heavy drinking, and non-regular exercise (physical inactivity). Outcomes included all-cause young-onset dementia, Alzheimer’s disease, and vascular dementia.</p> Results <p>The study included 1,979,509 patients (average age 49.05 ± 5.96, 51.27% male), with distribution across ULBS categories as follows: 14.5% ULBS 0, 62.3% ULBS 1, 19.5% ULBS 2, and 3.7% ULBS 3. After adjusting for multiple variables, patients with ULBS 1, 2, and 3 showed a significantly increased risk of all-cause young-onset dementia compared to those with ULBS 0 in a dose-response relationship. (Adjusted hazard ratio [95% CI]: 1.147 [1.077–1.221], 1.486 [1.376–1.604], and 1.909 [1.704–2.138], respectively).</p> Interpretation <p>The accumulation of unhealthy lifestyle behaviors is significantly linked to a higher risk of all-cause young-onset dementia. These findings underscore the importance of promoting healthy lifestyle choices to mitigate the risk of developing young-onset dementia.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between unhealthy lifestyles and young-onset dementia: a nationwide cohort study

  • 期刊论文

  • 发表日期：

    2026年2月12日

查看全文
  • Sangwon Choi,
  • Younggeun Choi,
  • Dae Young Cheon,
  • Jae-Sung Lim,
  • Kyung Do Han,
  • Minwoo Lee

摘要

Objectives

The link between clusters of unhealthy lifestyle behaviors and the risk of young-onset dementia remains unclear. This study aimed to assess the impact of multiple unhealthy lifestyle behaviors on the risk of developing young-onset dementia, including all-cause dementia, Alzheimer’s disease, and vascular dementia.

Methods

We analyzed nationwide Korean National Health Insurance Service data from individuals aged 40–60 years who underwent health screening in 2009 and were followed until 2018 or age 65. The Unhealthy Lifestyle Behavior Score (ULBS) was derived from smoking, heavy drinking, and non-regular exercise (physical inactivity). Outcomes included all-cause young-onset dementia, Alzheimer’s disease, and vascular dementia.

Results

The study included 1,979,509 patients (average age 49.05 ± 5.96, 51.27% male), with distribution across ULBS categories as follows: 14.5% ULBS 0, 62.3% ULBS 1, 19.5% ULBS 2, and 3.7% ULBS 3. After adjusting for multiple variables, patients with ULBS 1, 2, and 3 showed a significantly increased risk of all-cause young-onset dementia compared to those with ULBS 0 in a dose-response relationship. (Adjusted hazard ratio [95% CI]: 1.147 [1.077–1.221], 1.486 [1.376–1.604], and 1.909 [1.704–2.138], respectively).

Interpretation

The accumulation of unhealthy lifestyle behaviors is significantly linked to a higher risk of all-cause young-onset dementia. These findings underscore the importance of promoting healthy lifestyle choices to mitigate the risk of developing young-onset dementia.