Scholarlink

<p>Dysregulation of the endocannabinoid system (ECS) might be related to autism spectrum disorder (ASD). This study conducts a meta-analysis on the dysregulation of the ECS across ASD animal models and individuals with ASD and systematically reviews the impact of these alterations in ASD animal models. Out of 47 papers assessed for eligibility, 16 animal studies and five human studies were included for narrative synthesis and seven and three for quantitative analysis, respectively. The results revealed a significant decrease in hippocampus anandamide (AEA) levels (SMD = −1.06, 95% CI [−1.78, −0.33], <i>p</i> &lt; 0.01) among ASD animal&#xa0;models and a decrease in blood AEA levels in individuals with ASD (SMD = −0.79, 95% CI [−1.28, −0.30], <i>p</i> = 0.002) compared to normal controls. In the prefrontal cortex, 2-arachidonoylglycerol (2-AG) levels were significantly decreased, despite high heterogeneity between studies (SMD = −1.00, 95% CI [−1.93, −0.06], <i>p</i> = 0.04). No significant changes&#xa0;compared to normal controls were observed in levels of AEA (SMD = −0.48, 95% CI [−1.20, 0.25], <i>p</i> = 0.20), 2-AG (SMD = −0.62, 95% CI [−1.27, 0.02], <i>p</i> = 0.06) in combined brain regions. The narrative synthesis revealed that elevated AEA and 2-AG levels could ameliorate core and associated autistic-like symptoms with region and sex-dependent variations in ASD animal&#xa0;models. Future research should focus on specific mechanisms of endocannabinoids regional effects while considering sex-related influences.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Alterations of the endocannabinoid system in autism spectrum disorder: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年6月15日

查看全文
  • Xinlei Jia,
  • Shumin Gao,
  • Xiaotong Liu,
  • Zhendong Feng,
  • Xingxing Wang,
  • Kunyi Lan,
  • Yan’e Lu,
  • Lei Han,
  • Ya Bin Wei,
  • Jia Jia Liu

摘要

Dysregulation of the endocannabinoid system (ECS) might be related to autism spectrum disorder (ASD). This study conducts a meta-analysis on the dysregulation of the ECS across ASD animal models and individuals with ASD and systematically reviews the impact of these alterations in ASD animal models. Out of 47 papers assessed for eligibility, 16 animal studies and five human studies were included for narrative synthesis and seven and three for quantitative analysis, respectively. The results revealed a significant decrease in hippocampus anandamide (AEA) levels (SMD = −1.06, 95% CI [−1.78, −0.33], p < 0.01) among ASD animal models and a decrease in blood AEA levels in individuals with ASD (SMD = −0.79, 95% CI [−1.28, −0.30], p = 0.002) compared to normal controls. In the prefrontal cortex, 2-arachidonoylglycerol (2-AG) levels were significantly decreased, despite high heterogeneity between studies (SMD = −1.00, 95% CI [−1.93, −0.06], p = 0.04). No significant changes compared to normal controls were observed in levels of AEA (SMD = −0.48, 95% CI [−1.20, 0.25], p = 0.20), 2-AG (SMD = −0.62, 95% CI [−1.27, 0.02], p = 0.06) in combined brain regions. The narrative synthesis revealed that elevated AEA and 2-AG levels could ameliorate core and associated autistic-like symptoms with region and sex-dependent variations in ASD animal models. Future research should focus on specific mechanisms of endocannabinoids regional effects while considering sex-related influences.