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<p>We present a cross-sectional analysis of 1391 outpatients and 280 inpatients participating in subprojects of the Research Training Group POKAL, of whom 1609 had a PHQ-9 score ≥ 5 and 62 reported depression with antidepressant use. Antidepressant use was lower among outpatients than inpatients (28.5% vs. 82.5%), with higher levels of SSRI monotherapy (44.1% vs. 25.5%). Of antidepressant users, 80.1% had potentially inadequate treatment response, 21.7% high-risk use and of those with severe symptoms, 42.1% were potentially undertreated. Key risk factors were higher anxiety levels (for inadequate treatment response) and polypharmacy (for high-risk use), while previous depressive episode was protective against potential undertreatment.</p>

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Suboptimal antidepressant use among inpatients and outpatients with symptoms of depression: a cross-sectional analysis of the POKAL core data set

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月12日

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  • V. Brisnik,
  • M. Schechner,
  • P. Landmesser,
  • H. Schillok,
  • P. Schoenweger,
  • M. Rottenkolber,
  • D. Lindemann,
  • K. Lukaschek,
  • C. Jung-Sievers,
  • P. Falkai,
  • P. Henningsen,
  • G. Pitschel-Walz,
  • H. Krcmar,
  • A. Schneider,
  • C. Haas,
  • F. Gökce,
  • J. Eder,
  • L. Pfeiffer,
  • V. von Schrottenberg,
  • C. Teusen,
  • M. Bühner,
  • J. Gensichen,
  • T. Dreischulte

摘要

We present a cross-sectional analysis of 1391 outpatients and 280 inpatients participating in subprojects of the Research Training Group POKAL, of whom 1609 had a PHQ-9 score ≥ 5 and 62 reported depression with antidepressant use. Antidepressant use was lower among outpatients than inpatients (28.5% vs. 82.5%), with higher levels of SSRI monotherapy (44.1% vs. 25.5%). Of antidepressant users, 80.1% had potentially inadequate treatment response, 21.7% high-risk use and of those with severe symptoms, 42.1% were potentially undertreated. Key risk factors were higher anxiety levels (for inadequate treatment response) and polypharmacy (for high-risk use), while previous depressive episode was protective against potential undertreatment.