Objective <p>To review the current literature for epidemiology, cost, and global burden related to the management of laryngopharyngeal reflux disease (LPRD).</p> Method <p>Two independent investigators conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) systematic literature search for studies reporting LPRD incidence, prevalence, comorbidities, healthcare cost and global burden. Investigator used two validated clinical tools for carrying out the methodological bias analysis.</p> Results <p>Of 646 retrieved papers, thirty met inclusion criteria (20 epidemiological, 5 cost-burden, and 5 awareness studies). Prevalence varied substantially depending on diagnostic method and region, ranging from 5.0% to 58.3% in otolaryngology outpatients. Chinese studies consistently reported lower rates (5.0%–13.4%), whereas Middle East, and Western studies yielded higher estimates (20.9%–58.3%). The economic burden of LPRD appears substantial, exceeding that of gastroesophageal reflux disease, and is compounded by persistent gaps in practitioner awareness regarding diagnosis and management. The frequent use of empiric PPI therapy despite evidence of limited effectiveness in non-acid reflux contributes to unnecessary healthcare expenditures. Awareness surveys confirmed that general and specialist practitioners commonly lack key knowledge regarding LPRD diagnosis and management.</p> Conclusion <p>LPRD symptoms are prevalent the Middle East and Western country populations, with ineffective management, and related high-cost burden. Future studies are needed to specifically determine the incidence and prevalence using a gold standard, and the global cost for managing LPRD and associated diseases.</p>