Scholarlink

Objective <p>It is known that both adenoid hypertrophy (AH) and allergic rhinitis (AR) can cause obstructive sleep apnea (OSA), but their relative importance, especially when tonsil size is considered, remains unclear. This study aimed to compare the independent contributions of AR, AH, and tonsil hypertrophy to OSA severity and to determine the primary contributing factor.</p> Method <p>A total of 177 children aged 3 to 6 were included in the study. They were divided into four groups based on adenoid size (nasal endoscopic obstruction ≥ 75%) and AR (serum total IgE, inhalant-specific IgE, or clinical diagnosis): Group A (AH alone, <i>n</i> = 39), Group B (mixed factors, <i>n</i> = 63), Group C (AR alone, <i>n</i> = 53), and Group D (control, <i>n</i> = 22). OSA severity was assessed using the apnea-hypopnea index (AHI) measured by polysomnography. Intergroup comparisons were performed using the Kruskal-Wallis test. Spearman’s correlation analysis was used to evaluate the correlation between total IgE and AHI. A multivariate linear regression model was employed to identify independent predictors of ln_AHI.</p> Result <p>The AHI in Group B was significantly higher than that in Groups A, C, and D (<i>P</i> &lt; 0.05). Total IgE showed a weak but significant positive correlation with AHI (r_s = 0.15, <i>P</i> = 0.042). AR was the strongest independent predictor of ln_AHI (standardized β = 0.258, 95% CI: 0.095–0.311, <i>P</i> &lt; 0.0001), followed by tonsil size, BMI, adenoid size and gender, while age was not statistically significant.</p> Conclusion <p>Among preschool children, AR is the strongest independent predictor of OSA severity, followed by the size of the adenoid and tonsil. Clinically, for preschool children with OSA, assessing allergic status should be prioritized alongside evaluation of adenotonsillar anatomy, and anti‑allergic therapy should be considered as a key component of OSA management, either as a stand‑alone treatment in mild cases or as an adjunct to adenotonsillectomy in more severe cases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Allergic rhinitis is the strongest independent predictor of obstructive sleep apnea severity in preschool children

  • 期刊论文

  • 发表日期：

    2026年7月19日

查看全文
  • Linyuan Sima,
  • Junwen Fan

摘要

Objective

It is known that both adenoid hypertrophy (AH) and allergic rhinitis (AR) can cause obstructive sleep apnea (OSA), but their relative importance, especially when tonsil size is considered, remains unclear. This study aimed to compare the independent contributions of AR, AH, and tonsil hypertrophy to OSA severity and to determine the primary contributing factor.

Method

A total of 177 children aged 3 to 6 were included in the study. They were divided into four groups based on adenoid size (nasal endoscopic obstruction ≥ 75%) and AR (serum total IgE, inhalant-specific IgE, or clinical diagnosis): Group A (AH alone, n = 39), Group B (mixed factors, n = 63), Group C (AR alone, n = 53), and Group D (control, n = 22). OSA severity was assessed using the apnea-hypopnea index (AHI) measured by polysomnography. Intergroup comparisons were performed using the Kruskal-Wallis test. Spearman’s correlation analysis was used to evaluate the correlation between total IgE and AHI. A multivariate linear regression model was employed to identify independent predictors of ln_AHI.

Result

The AHI in Group B was significantly higher than that in Groups A, C, and D (P < 0.05). Total IgE showed a weak but significant positive correlation with AHI (r_s = 0.15, P = 0.042). AR was the strongest independent predictor of ln_AHI (standardized β = 0.258, 95% CI: 0.095–0.311, P < 0.0001), followed by tonsil size, BMI, adenoid size and gender, while age was not statistically significant.

Conclusion

Among preschool children, AR is the strongest independent predictor of OSA severity, followed by the size of the adenoid and tonsil. Clinically, for preschool children with OSA, assessing allergic status should be prioritized alongside evaluation of adenotonsillar anatomy, and anti‑allergic therapy should be considered as a key component of OSA management, either as a stand‑alone treatment in mild cases or as an adjunct to adenotonsillectomy in more severe cases.