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Purpose <p>Early-onset laryngeal cancer remains understudied despite its potential clinical and socioeconomic impact in adolescents and adults of working age. We aimed to describe the global, regional, and national burden of laryngeal cancer among individuals aged 15–49&#xa0;years using data from the Global Burden of Disease (GBD) 2021 study.</p> Methods <p>Data from the Global Burden of Disease (GBD) 2021 study were used to estimate incidence, mortality, disability-adjusted life years (DALYs), and attributable risk factors of laryngeal cancer among individuals aged 15–49 across 204 countries and territories from 1990 to 2021. Age-standardized rates (ASRs) and Joinpoint regression were applied to assess temporal trends, while associations with socio-demographic index (SDI) and risk factors were evaluated.</p> Results <p>In 2021, early-onset laryngeal cancer accounted for 36,855 cases (ASR: 0.48/100,000), 19,550 deaths (ASR: 0.26/100,000), and 935,561 DALYs (ASR: 12.35/100,000) globally. The global age-standardized incidence rate (ASIR) in males was 4.39 times that in females. From 1990 to 2021, global age-standardized incidence and mortality generally declined, whereas incidence increased among females in Asia. Mortality and DALY rates were inversely associated with SDI, while incidence showed no significant correlation with SDI. Sulfuric acid exposure was the only factor associated with an increase in attributable mortality and DALYs over time, whereas smoking, alcohol use, and asbestos exposure showed declining attributable burdens.</p> Conclusion <p>Although the global burden of early-onset laryngeal cancer decreased from 1990 to 2021, marked sex- and region-specific disparities remained. Males bore a higher burden overall, and distinct regional patterns were observed, including a rising incidence among females in Asia. These findings provide a global descriptive overview of early-onset laryngeal cancer and may help inform future etiological research and region-specific prevention priorities.</p> Clinical trial number <p>not applicable.</p>

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Burden of early-onset laryngeal cancer in individuals aged 15–49 years: global, regional, and national estimates from the GBD 2021 study

  • 期刊论文

  • 发表日期：

    2026年7月5日

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  • DuanShaLi Liu,
  • YueHao Lu,
  • BeiCheng Li,
  • QingHua Liu,
  • Ge Gao,
  • ShiKang Zheng,
  • Zhe Yang,
  • XiaoHan Li,
  • Kai Zhao,
  • MingBo Liu

摘要

Purpose

Early-onset laryngeal cancer remains understudied despite its potential clinical and socioeconomic impact in adolescents and adults of working age. We aimed to describe the global, regional, and national burden of laryngeal cancer among individuals aged 15–49 years using data from the Global Burden of Disease (GBD) 2021 study.

Methods

Data from the Global Burden of Disease (GBD) 2021 study were used to estimate incidence, mortality, disability-adjusted life years (DALYs), and attributable risk factors of laryngeal cancer among individuals aged 15–49 across 204 countries and territories from 1990 to 2021. Age-standardized rates (ASRs) and Joinpoint regression were applied to assess temporal trends, while associations with socio-demographic index (SDI) and risk factors were evaluated.

Results

In 2021, early-onset laryngeal cancer accounted for 36,855 cases (ASR: 0.48/100,000), 19,550 deaths (ASR: 0.26/100,000), and 935,561 DALYs (ASR: 12.35/100,000) globally. The global age-standardized incidence rate (ASIR) in males was 4.39 times that in females. From 1990 to 2021, global age-standardized incidence and mortality generally declined, whereas incidence increased among females in Asia. Mortality and DALY rates were inversely associated with SDI, while incidence showed no significant correlation with SDI. Sulfuric acid exposure was the only factor associated with an increase in attributable mortality and DALYs over time, whereas smoking, alcohol use, and asbestos exposure showed declining attributable burdens.

Conclusion

Although the global burden of early-onset laryngeal cancer decreased from 1990 to 2021, marked sex- and region-specific disparities remained. Males bore a higher burden overall, and distinct regional patterns were observed, including a rising incidence among females in Asia. These findings provide a global descriptive overview of early-onset laryngeal cancer and may help inform future etiological research and region-specific prevention priorities.

Clinical trial number

not applicable.