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Objective <p>Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, and parathyroidectomy remains the definitive treatment. This study aimed to evaluate the demographic characteristics, clinical presentation, localization accuracy of imaging modalities, and surgical outcomes of patients who underwent parathyroidectomy for PHPT.</p> Methods <p>A retrospective analysis was performed on patients who underwent parathyroidectomy for PHPT in a tertiary otorhinolaryngology clinic between April 2015 and August 2025. Demographic data, clinical and biochemical findings, preoperative imaging results, histopathological outcomes, and postoperative complications were analyzed. Surgical success was defined as normalization of serum calcium and parathyroid hormone (PTH) levels. Intraoperative PTH (iPTH) monitoring was used to assess surgical efficacy.</p> Results <p>A total of 115 parathyroid procedures were performed in 112 patients (81.3% female), with a mean age of 55.2 years. At diagnosis, 51% of patients were asymptomatic, while 49% were symptomatic. Parathyroid adenoma was identified in 91% of patients, hyperplasia in 6.3%, and parathyroid carcinoma in 2.7%. Ectopic parathyroid adenomas were detected in 3.8% of cases. The sensitivity of ultrasonography, sestamibi scintigraphy, and computed tomography for lesion localization was 84.3%, 80.4%, and 74.0%, respectively. Surgical success was achieved in 97.2% of patients based on biochemical normalization and follow-up results. No cases of permanent hypoparathyroidism, recurrent laryngeal nerve paralysis, hematoma, or hungry bone syndrome were observed.</p> Conclusion <p>Parathyroidectomy is a highly effective and safe treatment for primary hyperparathyroidism when performed in tertiary centers with a multidisciplinary approach. Intraoperative PTH monitoring and complementary use of imaging modalities contribute to high surgical success with low morbidity.</p>

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Clinical outcomes of parathyroidectomy in primary hyperparathyroidism: a 10-year single-center experience with 115 procedures

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Erdoğan Ozgür,
  • Salim Hancı,
  • Ersoy Doğan,
  • Nuri Karabay,
  • Ozhan Ozdoğan,
  • Ozden Ozdemir Başer,
  • Abdurrahman Cömlekçi,
  • Ahmet Omer Ikiz

摘要

Objective

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, and parathyroidectomy remains the definitive treatment. This study aimed to evaluate the demographic characteristics, clinical presentation, localization accuracy of imaging modalities, and surgical outcomes of patients who underwent parathyroidectomy for PHPT.

Methods

A retrospective analysis was performed on patients who underwent parathyroidectomy for PHPT in a tertiary otorhinolaryngology clinic between April 2015 and August 2025. Demographic data, clinical and biochemical findings, preoperative imaging results, histopathological outcomes, and postoperative complications were analyzed. Surgical success was defined as normalization of serum calcium and parathyroid hormone (PTH) levels. Intraoperative PTH (iPTH) monitoring was used to assess surgical efficacy.

Results

A total of 115 parathyroid procedures were performed in 112 patients (81.3% female), with a mean age of 55.2 years. At diagnosis, 51% of patients were asymptomatic, while 49% were symptomatic. Parathyroid adenoma was identified in 91% of patients, hyperplasia in 6.3%, and parathyroid carcinoma in 2.7%. Ectopic parathyroid adenomas were detected in 3.8% of cases. The sensitivity of ultrasonography, sestamibi scintigraphy, and computed tomography for lesion localization was 84.3%, 80.4%, and 74.0%, respectively. Surgical success was achieved in 97.2% of patients based on biochemical normalization and follow-up results. No cases of permanent hypoparathyroidism, recurrent laryngeal nerve paralysis, hematoma, or hungry bone syndrome were observed.

Conclusion

Parathyroidectomy is a highly effective and safe treatment for primary hyperparathyroidism when performed in tertiary centers with a multidisciplinary approach. Intraoperative PTH monitoring and complementary use of imaging modalities contribute to high surgical success with low morbidity.