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Purpose <p>This study aimed to evaluate serum Otolin-1 levels in patients with Ménière’s disease (MD) and Vestibular migraine (VM) and to investigate its potential diagnostic utility.</p> Methods <p>Ninety participants were recruited, including 30 patients with MD, 30 with VM, and 30 healthy controls. Serum Otolin-1 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA).</p> Results <p>Otolin-1 levels differed significantly among the groups, with highest levels observed in VM (641.7 ± 106.2 pg/mL), intermediate levels in MD (539.9 ± 107.3 pg/mL), and lowest levels in controls (358.6 ± 208.8 pg/mL). ROC analysis for VM versus controls yielded an AUC of 0.918, with an optimal cutoff of ~ 553 pg/mL, providing 90.0% sensitivity and 83.3% specificity.</p> Conclusion <p>These findings support Otolin-1 as a promising complementary biomarker for the differential diagnosis of recurrent vestibular syndromes. Larger multicenter prospective studies are needed to confirm diagnostic and prognostic applicability.</p>

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Serum otolin-1 levels in vestibular migraine and Ménière’s disease: a comparative clinical study

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Halil Elden,
  • Mahmut Sinan Yilmaz,
  • Mustafa Altindis,
  • Gulcin Akca,
  • Ahmet Cihan,
  • Gulden Vural

摘要

Purpose

This study aimed to evaluate serum Otolin-1 levels in patients with Ménière’s disease (MD) and Vestibular migraine (VM) and to investigate its potential diagnostic utility.

Methods

Ninety participants were recruited, including 30 patients with MD, 30 with VM, and 30 healthy controls. Serum Otolin-1 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA).

Results

Otolin-1 levels differed significantly among the groups, with highest levels observed in VM (641.7 ± 106.2 pg/mL), intermediate levels in MD (539.9 ± 107.3 pg/mL), and lowest levels in controls (358.6 ± 208.8 pg/mL). ROC analysis for VM versus controls yielded an AUC of 0.918, with an optimal cutoff of ~ 553 pg/mL, providing 90.0% sensitivity and 83.3% specificity.

Conclusion

These findings support Otolin-1 as a promising complementary biomarker for the differential diagnosis of recurrent vestibular syndromes. Larger multicenter prospective studies are needed to confirm diagnostic and prognostic applicability.