Background <p>The aim of this study was to investigate the efficacy of concentrated growth factor (CGF) in type 1 tympanoplasty.</p> Methods <p>This study represents a retrospective analysis of a non-randomized interventional cohort study, included 60 patients who underwent primary type 1 tympanoplasty between November 2024 and July 2025. The patients were divided into those who received only a cartilage graft (<i>n</i> = 30) and those who received a cartilage graft and CGF (<i>n</i> = 30). The incidence rates of residual tympanic membrane perforation, audiological outcomes, and postoperative infection rates were compared.</p> Results <p>The incidence rate of residual perforation was significantly lower in the CGF group than in the cartilage-only group. The audiological outcomes showed no significant differences between the groups. Postoperative infection was observed less frequently in the CGF group.</p> Conclusion <p>CGF may represent a promising adjunct in type 1 tympanoplasty by potentially supporting graft integration and reducing residual perforation rates.</p>