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Purpose <p>Mucoepidermoid carcinoma (MEC) is the most common malignant histology encountered in salivary glands. Due to the rarity of salivary gland malignancies and more than 20 different histological types, there is a need to analyse clinicopathological risk factors of each histology separately, with emphasis on long-term outcomes.</p> Methods <p>Retrospective cohort study from a tertiary care centre conducted from 2014 to 2024 on all histologically confirmed MEC that underwent upfront surgery.</p> Results <p>244 MEC [major salivary gland (MASG)-153, minor salivary gland (MISG)-91] were available for analysis. The median follow-up was 39 months. Location in MISG, higher T category and female sex were independent prognostic variables for survival on multivariate analysis (MVA) of the entire cohort. The impact of tumour location persisted following matched-pair analysis controlling for tumour stage, grade and margin status (OS: HR:5.3, 95% CI: 2.1 to 12.9; DFS: HR: 2.7, 95% CI: 1.2 to 5.8). The predominant pattern of failure for tumour located in MISG was distant metastasis, whereas in MASG, loco-regional failure was commonly encountered. In terms of tumour grade, low-grade and high-grade had the best and worst outcomes for both MASG and MISG. However, survival curves for intermediate-grade tumours clustered with low-grade tumours in MASG and with high-grade tumours in MISG.</p> Conclusion <p>Tumour location demonstrated a pronounced impact on MEC outcomes following treatment, independent of AJCC staging and histological grade.</p>

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Does the site of origin of mucoepidermoid carcinoma impact treatment outcomes? Long-term analysis of 244 patients over a decade

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Smriti Panda,
  • Karthika Chettuvatti,
  • Rajeev Kumar,
  • Alok Thakar,
  • Kapil Sikka,
  • Chirom Amit Singh,
  • Rakesh Kumar,
  • Rachit Sood,
  • Thalhath A Salam,
  • Kavneet Kaur,
  • Aman Sharma,
  • Akash Kumar,
  • Ahitagni Biswas,
  • Suman Bhaskar,
  • Aanchal Kakkar

摘要

Purpose

Mucoepidermoid carcinoma (MEC) is the most common malignant histology encountered in salivary glands. Due to the rarity of salivary gland malignancies and more than 20 different histological types, there is a need to analyse clinicopathological risk factors of each histology separately, with emphasis on long-term outcomes.

Methods

Retrospective cohort study from a tertiary care centre conducted from 2014 to 2024 on all histologically confirmed MEC that underwent upfront surgery.

Results

244 MEC [major salivary gland (MASG)-153, minor salivary gland (MISG)-91] were available for analysis. The median follow-up was 39 months. Location in MISG, higher T category and female sex were independent prognostic variables for survival on multivariate analysis (MVA) of the entire cohort. The impact of tumour location persisted following matched-pair analysis controlling for tumour stage, grade and margin status (OS: HR:5.3, 95% CI: 2.1 to 12.9; DFS: HR: 2.7, 95% CI: 1.2 to 5.8). The predominant pattern of failure for tumour located in MISG was distant metastasis, whereas in MASG, loco-regional failure was commonly encountered. In terms of tumour grade, low-grade and high-grade had the best and worst outcomes for both MASG and MISG. However, survival curves for intermediate-grade tumours clustered with low-grade tumours in MASG and with high-grade tumours in MISG.

Conclusion

Tumour location demonstrated a pronounced impact on MEC outcomes following treatment, independent of AJCC staging and histological grade.