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Purpose <p>Low-cost tools are needed to differentiate normal from abnormal vocal fold mobility in resource-limited settings or in absence of laryngoscopic examination tools.</p> Method <p>This is a prospective observational pilot study. Acoustic samples were recorded on the OperaVOX app to detect unilateral vocal fold paralysis/paresis (UVFP).</p> Results <p>Seventy participants were enrolled in two parallel cohorts (37 cases, 33 controls), 43 (61.4%) were females. Comparing cases to controls, there were significant differences in F2, jitter, shimmer, shimmer (dB), and harmonic to noise ratio (HNR), (<i>P</i> &lt; 0.05). Multiple parameters demonstrated moderate accuracy (area-under-the-curve (AUC) &gt; 0.7) in all patients, females and male. Logistic regression identified parameters that significantly predicted UVFP in all patients, females-only and males-only. Lastly, multiple cut-off values with variable sensitivity/specificity performances were identified to support the use of OperaVOX as a screening tool based on the logistic regression results.</p> Conclusions <p>This pilot study identified cutoff values of acoustic parameters collected by OperaVOX with sensitivity/specificity as a potential screening tool for dysphonia to identify patients to be referred for laryngeal examination. Future studies in resource-limited-settings are needed to validate our results.</p>

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Prospective pilot study of a smartphone app as a screening tool for unilateral vocal fold paresis/paralysis

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • Selen Soylu,
  • Okenwa C. Okose,
  • Yufei Chen,
  • Bo Wang,
  • Marika D. Russell,
  • Dipti Kamani,
  • Vishwanatha M. Rao,
  • Dioan McIlroy,
  • Karissa L. LeClair,
  • Jarrett M. Jackson,
  • Ian J. Behr,
  • Anthony Y. Cheung,
  • Lily N. Trinh,
  • Yoshiyuki Saito,
  • Amr H. Abdelhamid Ahmed,
  • Phillip C. Song,
  • Gregory W. Randolph

摘要

Purpose

Low-cost tools are needed to differentiate normal from abnormal vocal fold mobility in resource-limited settings or in absence of laryngoscopic examination tools.

Method

This is a prospective observational pilot study. Acoustic samples were recorded on the OperaVOX app to detect unilateral vocal fold paralysis/paresis (UVFP).

Results

Seventy participants were enrolled in two parallel cohorts (37 cases, 33 controls), 43 (61.4%) were females. Comparing cases to controls, there were significant differences in F2, jitter, shimmer, shimmer (dB), and harmonic to noise ratio (HNR), (P < 0.05). Multiple parameters demonstrated moderate accuracy (area-under-the-curve (AUC) > 0.7) in all patients, females and male. Logistic regression identified parameters that significantly predicted UVFP in all patients, females-only and males-only. Lastly, multiple cut-off values with variable sensitivity/specificity performances were identified to support the use of OperaVOX as a screening tool based on the logistic regression results.

Conclusions

This pilot study identified cutoff values of acoustic parameters collected by OperaVOX with sensitivity/specificity as a potential screening tool for dysphonia to identify patients to be referred for laryngeal examination. Future studies in resource-limited-settings are needed to validate our results.