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Background <p>Inverted papilloma (IP) is a benign Schneiderian epithelial tumour with a well-recognized potential for recurrence and malignant transformation, most commonly to squamous cell carcinoma (SCC). Carcinoma arising in the nasopharynx after prior IP is exceedingly rare, and distinguishing malignant conversion from a metachronous nasopharyngeal carcinoma (NPC) poses a diagnostic challenge.</p> Case report <p>We report a rare, interesting case of a nasopharyngeal lesion with histopathological features of non-keratinizing SCC in a patient previously treated surgically for sinonasal IP.</p> Conclusion <p>Differentiating malignant transformation of IP from a metachronous malignancy is complex. In this case, the short interval between diagnoses, anatomical separation, and absence of Schneiderian features favour interpretation as a metachronous NPC, highlighting the importance of continued surveillance and prompt evaluation of new symptoms in patients treated for IP.</p>

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Metachronous nasopharyngeal carcinoma following sinonasal inverted papilloma – a diagnostic enigma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月20日

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  • Deviprasad Dosemane,
  • Meera Niranjan Khadilkar,
  • Nithya Chandy,
  • Divya Subramanian,
  • Nayana Rao,
  • Susana Iqbal

摘要

Background

Inverted papilloma (IP) is a benign Schneiderian epithelial tumour with a well-recognized potential for recurrence and malignant transformation, most commonly to squamous cell carcinoma (SCC). Carcinoma arising in the nasopharynx after prior IP is exceedingly rare, and distinguishing malignant conversion from a metachronous nasopharyngeal carcinoma (NPC) poses a diagnostic challenge.

Case report

We report a rare, interesting case of a nasopharyngeal lesion with histopathological features of non-keratinizing SCC in a patient previously treated surgically for sinonasal IP.

Conclusion

Differentiating malignant transformation of IP from a metachronous malignancy is complex. In this case, the short interval between diagnoses, anatomical separation, and absence of Schneiderian features favour interpretation as a metachronous NPC, highlighting the importance of continued surveillance and prompt evaluation of new symptoms in patients treated for IP.