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Purpose <p>Squamous cell carcinoma of the tongue (TSCC) is the most common cancer of the oral cavity accounting for 25–40% of the cases. Its unfavorable prognosis is partly attributed to the high incidence of lymph node metastasis, while lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival. The purpose of this study was to conduct a systematic review and meta-analysis, that evaluates the prognostic significance of LVD regarding nodal metastasis in TSCC, focusing on intratumoral and peritumoral LVD.</p> Methods <p>The studies included referred to patients with TSCC who underwent tumor resection and LVD was estimated via immunohistochemistry (D2-40, LYVE-1). Literature search and data extraction were performed by two independent reviewers. Hazard ratios (HRs) and mean differences were calculated using fixed-effects or random-effects models and heterogeneity was assessed via I² statistics. A total of 26 studies were identified, with 6 meeting eligibility criteria.</p> Results <p>The principal outcome was the significant association between high overall LVD and increased nodal metastasis (summary mean difference: 0.85; 95% CI: 0.21, 1.49; p= 0.010, I²=77.6%). No statistically significant association was observed for intratumoral (summary HR: 0.23; 95% CI: -0.45, 0.92; p = 0.501, I²=81%) or peritumoral LVD (summary HR: 0.10; 95% CI: -0.80, 0.99; p = 0.832, I²=89.8%).</p> Conclusion <p>The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.</p>

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The prognostic value of lymphatic vessel density in squamous cell carcinoma of the tongue: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Aikaterini Marini,
  • Roubini Zakopoulou,
  • Georgios Ntritsos,
  • Kalliopi Iliou,
  • Christos Giannousis,
  • Dimitrios Varvarousis,
  • Panagiotis Kitsoulis,
  • Thomas Iraklis Smyris,
  • Asimakis Asimakopoulos,
  • Theocharis Chatzoglou

摘要

Purpose

Squamous cell carcinoma of the tongue (TSCC) is the most common cancer of the oral cavity accounting for 25–40% of the cases. Its unfavorable prognosis is partly attributed to the high incidence of lymph node metastasis, while lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival. The purpose of this study was to conduct a systematic review and meta-analysis, that evaluates the prognostic significance of LVD regarding nodal metastasis in TSCC, focusing on intratumoral and peritumoral LVD.

Methods

The studies included referred to patients with TSCC who underwent tumor resection and LVD was estimated via immunohistochemistry (D2-40, LYVE-1). Literature search and data extraction were performed by two independent reviewers. Hazard ratios (HRs) and mean differences were calculated using fixed-effects or random-effects models and heterogeneity was assessed via I² statistics. A total of 26 studies were identified, with 6 meeting eligibility criteria.

Results

The principal outcome was the significant association between high overall LVD and increased nodal metastasis (summary mean difference: 0.85; 95% CI: 0.21, 1.49; p= 0.010, I²=77.6%). No statistically significant association was observed for intratumoral (summary HR: 0.23; 95% CI: -0.45, 0.92; p = 0.501, I²=81%) or peritumoral LVD (summary HR: 0.10; 95% CI: -0.80, 0.99; p = 0.832, I²=89.8%).

Conclusion

The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.