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Purpose <p>The purpose of this study is to compare office-based laser therapy (OBLT) to intralesional steroid injections (ILSI) in the treatment of Reinke’s edema (RE).</p> Methods <p>The medical records and video-recordings of patients diagnosed with RE who underwent office-based therapy at the Voice and Swallowing Unit between November 2022 and December 2024 were reviewed. The primary outcome measures used were disease regression and patient-reported improvement in voice quality. Secondary outcome measures included acoustic voice parameters.</p> Results <p>A total of 19 patients were included in the study, with a mean age of 55 ± 13.28 years. Two patients had unilateral disease while 17 had bilateral disease (total of 36 lesions). Seventeen lesions were rated as type 1, two as type 2 and fourteen as type 3. Partial disease regression was noted in 24 lesions (66.7%) and complete disease regression was noted in 12 lesions (33.3%). There was no statistically significant difference in partial or complete disease regression between OBLT and ILSI (<i>p</i> = 0.414 and <i>p</i> = 0.248, respectively). There was no statistically significant difference in the drop of mean VHI-10 scores between the two groups (<i>p</i> = 0.252). There was also no significant difference in the change in any of the acoustic parameters.</p> Conclusion <p>OBLT and ILSI are effective in treating RE. There was no significant difference in any of the outcome measures between the two approaches. A larger sample size is needed to establish if there are disease-related differences, such as type of RE using either treatment modality.</p>

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Comparison between intralesional steroid injection vs. blue laser therapy for Reinke’s edema in an office setting: a case study

  • 期刊论文

  • 发表日期：

    2025年10月24日

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  • Abdul-Latif Hamdan,
  • Lana Ghzayel,
  • Zeina Maria Semaan,
  • Jonathan Abou Chaar,
  • Omar Aboul Hosn,
  • Ibana Carapiperis,
  • Patrick Abou Raji Feghali

摘要

Purpose

The purpose of this study is to compare office-based laser therapy (OBLT) to intralesional steroid injections (ILSI) in the treatment of Reinke’s edema (RE).

Methods

The medical records and video-recordings of patients diagnosed with RE who underwent office-based therapy at the Voice and Swallowing Unit between November 2022 and December 2024 were reviewed. The primary outcome measures used were disease regression and patient-reported improvement in voice quality. Secondary outcome measures included acoustic voice parameters.

Results

A total of 19 patients were included in the study, with a mean age of 55 ± 13.28 years. Two patients had unilateral disease while 17 had bilateral disease (total of 36 lesions). Seventeen lesions were rated as type 1, two as type 2 and fourteen as type 3. Partial disease regression was noted in 24 lesions (66.7%) and complete disease regression was noted in 12 lesions (33.3%). There was no statistically significant difference in partial or complete disease regression between OBLT and ILSI (p = 0.414 and p = 0.248, respectively). There was no statistically significant difference in the drop of mean VHI-10 scores between the two groups (p = 0.252). There was also no significant difference in the change in any of the acoustic parameters.

Conclusion

OBLT and ILSI are effective in treating RE. There was no significant difference in any of the outcome measures between the two approaches. A larger sample size is needed to establish if there are disease-related differences, such as type of RE using either treatment modality.