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Background <p>The aim of the present study was to evaluate the sex-disparities in larynx cancer patients treated with CO<sub>2-</sub>Transoral Laser Microsurgery (CO<sub>2</sub>-TOLMS).</p> Methods <p>Retrospective analysis of 1290 consecutive patients. Oncologic and functional outcomes were evaluated according to sex groups. Survival rates were compared by propensity-score matching approach and multivariable Cox regression analysis.</p> Results <p>Among 1290 patients, 122 (9.5%) were females. No significant differences were observed in tumor exposure, margins or pathology characteristics. Women experienced fewer complications than men (0.12 vs. 0.06; <i>p</i> = 0.007). There were neither significant differences in voice or swallowing outcomes, nor in the need for tracheostomy or gastrostomy. 5-y disease-free (63% vs. 66%, <i>p</i> = 0.92), 5-y disease-specific (91% vs. 93%, <i>p</i> = 0.54) and 5-y overall survival (78% vs. 84%, <i>p</i> = 0.18) rates were not different between men and woman.</p> Conclusions <p>CO<sub>2</sub>-TOLMS is a valid treatment for larynx cancer in women, with equivalent outcomes than those achieved in the male population.</p>

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Sex differences in laryngeal cancer treated with CO2-transoral laser microsurgery: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月14日

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  • Isabel Vilaseca,
  • C. Sampieri,
  • E. Lehrer,
  • R. D. Ramírez,
  • J. M. Costa,
  • I. Valduvieco,
  • N. Basté,
  • S. Medrano,
  • Y. Rodriguez,
  • A. Muxí,
  • F. X. Avilés-Jurado,
  • M. Bernal-Sprekelsen

摘要

Background

The aim of the present study was to evaluate the sex-disparities in larynx cancer patients treated with CO2-Transoral Laser Microsurgery (CO2-TOLMS).

Methods

Retrospective analysis of 1290 consecutive patients. Oncologic and functional outcomes were evaluated according to sex groups. Survival rates were compared by propensity-score matching approach and multivariable Cox regression analysis.

Results

Among 1290 patients, 122 (9.5%) were females. No significant differences were observed in tumor exposure, margins or pathology characteristics. Women experienced fewer complications than men (0.12 vs. 0.06; p = 0.007). There were neither significant differences in voice or swallowing outcomes, nor in the need for tracheostomy or gastrostomy. 5-y disease-free (63% vs. 66%, p = 0.92), 5-y disease-specific (91% vs. 93%, p = 0.54) and 5-y overall survival (78% vs. 84%, p = 0.18) rates were not different between men and woman.

Conclusions

CO2-TOLMS is a valid treatment for larynx cancer in women, with equivalent outcomes than those achieved in the male population.