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<p>Spiradenocarcinoma (SC) is a rare malignant adnexal tumor that arises from benign spiradenomas and exhibits aggressive behavior with metastatic potential. Due to its rarity, SC presents significant diagnostic challenges, and standardized treatment guidelines have yet to be established. This systematic review examines the available literature to provide a comprehensive overview of its clinical presentation, histopathologic features, and current management approaches. A thorough literature search was conducted following PRISMA guidelines to identify relevant studies reporting SC cases. The review highlights the importance of early recognition and accurate histopathologic differentiation from other adnexal tumors. While surgical excision remains the primary treatment, the role of other therapeutic options should be explored. Variability in classification, reporting, and follow-up data highlights the need for further research and standardized documentation. Increased awareness and further studies are essential to refining diagnostic criteria and optimizing treatment strategies for improved patient outcomes.</p>

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Spiradenocarcinoma: a systematic review of clinical features, diagnosis, and highlighting surgical management of a rare malignant cutaneous adnexal tumor

  • 期刊论文

  • 发表日期：

    2026年8月3日

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  • D. O. Leo Wan,
  • B. A. Lanah Almatroud,
  • B. S. Aileen Park,
  • Amor Khachemoune

摘要

Spiradenocarcinoma (SC) is a rare malignant adnexal tumor that arises from benign spiradenomas and exhibits aggressive behavior with metastatic potential. Due to its rarity, SC presents significant diagnostic challenges, and standardized treatment guidelines have yet to be established. This systematic review examines the available literature to provide a comprehensive overview of its clinical presentation, histopathologic features, and current management approaches. A thorough literature search was conducted following PRISMA guidelines to identify relevant studies reporting SC cases. The review highlights the importance of early recognition and accurate histopathologic differentiation from other adnexal tumors. While surgical excision remains the primary treatment, the role of other therapeutic options should be explored. Variability in classification, reporting, and follow-up data highlights the need for further research and standardized documentation. Increased awareness and further studies are essential to refining diagnostic criteria and optimizing treatment strategies for improved patient outcomes.