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<p>Although Mycosis Fungoides (MF) and Sézary Syndrome (SS) are the most common forms of cutaneous T-cell lymphoma, little has been reported on non-cancer Cause of Death (COD) in such patients. Assess COD for U.S. patients diagnosed with MF or SS. Determine nationwide standardized mortality ratios for non-cancer COD in patients diagnosed with MF or SS. The Surveillance, Epidemiology, and End Results (SEER) database (2000–2020) was utilized to extract data (including COD) from records of patients with an MF or SS diagnosis. Frequency and standardized mortality ratios (SMRs) for non-cancer COD were calculated. Of 7,344 patients diagnosed with MF or SS, 1,782 (24.3%) died during follow-up. Of these, 770 (43.2%) had a non-cancer COD, while 1,012 (56.8%) had a cancer-designated COD. For non-cancer COD, the most common cause was Cardiovascular Disease (30.9%, SMR: 2.29), followed by Cerebrovascular Diseases (7.0%, SMR: 2.22), COPD (6.6%, SMR: 2.11), Alzheimer’s Disease (4.2%, SMR: 1.76), Pneumonia and Influenza (3.6%; SMR: 3.93), and Septicemia (3.6%, SMR: 7.65). Notably, all causes for non-cancer COD were statistically significantly higher than that of the general population except for Alzheimer’s Disease. In this US-based population analysis, non-cancer COD accounted for almost half of the deaths for patients diagnosed with MF or SS. Cardiovascular Disease, usually preventable and treatable, was the leading non-cancer COD. These findings highlight the need for ongoing surveillance and counseling about common comorbidities for survivors of MF and SS.</p>

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Non-cancer causes of death for patients with mycosis fungoides or Sézary syndrome from 2000 to 2020: a US population-based analysis of SEER patient data

  • 期刊论文

  • 发表日期：

    2026年7月20日

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  • Michelle M. Kwan,
  • Walter J. Liszewski,
  • Dennis P. West,
  • Beatrice Nardone

摘要

Although Mycosis Fungoides (MF) and Sézary Syndrome (SS) are the most common forms of cutaneous T-cell lymphoma, little has been reported on non-cancer Cause of Death (COD) in such patients. Assess COD for U.S. patients diagnosed with MF or SS. Determine nationwide standardized mortality ratios for non-cancer COD in patients diagnosed with MF or SS. The Surveillance, Epidemiology, and End Results (SEER) database (2000–2020) was utilized to extract data (including COD) from records of patients with an MF or SS diagnosis. Frequency and standardized mortality ratios (SMRs) for non-cancer COD were calculated. Of 7,344 patients diagnosed with MF or SS, 1,782 (24.3%) died during follow-up. Of these, 770 (43.2%) had a non-cancer COD, while 1,012 (56.8%) had a cancer-designated COD. For non-cancer COD, the most common cause was Cardiovascular Disease (30.9%, SMR: 2.29), followed by Cerebrovascular Diseases (7.0%, SMR: 2.22), COPD (6.6%, SMR: 2.11), Alzheimer’s Disease (4.2%, SMR: 1.76), Pneumonia and Influenza (3.6%; SMR: 3.93), and Septicemia (3.6%, SMR: 7.65). Notably, all causes for non-cancer COD were statistically significantly higher than that of the general population except for Alzheimer’s Disease. In this US-based population analysis, non-cancer COD accounted for almost half of the deaths for patients diagnosed with MF or SS. Cardiovascular Disease, usually preventable and treatable, was the leading non-cancer COD. These findings highlight the need for ongoing surveillance and counseling about common comorbidities for survivors of MF and SS.