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Abstract <p>Investigating collagen alterations is crucial for understanding wound healing mechanisms and developing targeted therapies. Traditional histological evaluations of collagen involve invasive biopsies, posing discomfort to patients. Reflectance Confocal Microscopy (RCM) offers a non-invasive alternative, providing real-time imaging of collagen at cellular and subcellular levels. To explore the feasibility of using RCM to characterize collagen features of scars at various ages, as well as neighboring healthy skin.&#xa0;Scars and neighboring healthy skin were imaged using Vivascope 1500 reflective confocal microscopy technology. One RCM trained dermatopathologist assessed collagen features including organization, density, thickness, and presence or absence of inflammation. Scars were considered new if aged ≤ 2 months, intermediate between 2 and 12 months, and mature if older than 12 months).&#xa0;Fifteen scars in patients ages 15–66 were assessed. 10/15 scars were secondary to trauma and the remaining scars were from biopsies or planned procedures. The findings on RCM for collagen organization, density, thickness, and inflammation are consistent with histological analyses and show similar inflammatory, proliferative, and remodeling phases, demonstrating significant scar-age dependent alterations in collagen distribution in scar tissue.&#xa0;Small, heterogenous sample; one trained assessor; qualitative design; short study duration; lack of histological validation.&#xa0;RCM may be used as an imaging tool to assess scar formation. Differences noted between new and mature scars demonstrate progression of tissue through inflammatory, proliferative, and remodeling phases of wound healing. Understanding these differences may allow physicians to tailor treatments more accurately, ensuring that interventions are targeted, effective, and promote optimal healing.</p>

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Characterization of collagen in human scar tissue at various stages of scar maturation using in vivo reflectance confocal microscopy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月11日

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  • Aarushi K. Parikh,
  • Noah Musolff,
  • Madeline Tchack,
  • Tess Lukowiak,
  • Babar Rao

摘要

Abstract

Investigating collagen alterations is crucial for understanding wound healing mechanisms and developing targeted therapies. Traditional histological evaluations of collagen involve invasive biopsies, posing discomfort to patients. Reflectance Confocal Microscopy (RCM) offers a non-invasive alternative, providing real-time imaging of collagen at cellular and subcellular levels. To explore the feasibility of using RCM to characterize collagen features of scars at various ages, as well as neighboring healthy skin. Scars and neighboring healthy skin were imaged using Vivascope 1500 reflective confocal microscopy technology. One RCM trained dermatopathologist assessed collagen features including organization, density, thickness, and presence or absence of inflammation. Scars were considered new if aged ≤ 2 months, intermediate between 2 and 12 months, and mature if older than 12 months). Fifteen scars in patients ages 15–66 were assessed. 10/15 scars were secondary to trauma and the remaining scars were from biopsies or planned procedures. The findings on RCM for collagen organization, density, thickness, and inflammation are consistent with histological analyses and show similar inflammatory, proliferative, and remodeling phases, demonstrating significant scar-age dependent alterations in collagen distribution in scar tissue. Small, heterogenous sample; one trained assessor; qualitative design; short study duration; lack of histological validation. RCM may be used as an imaging tool to assess scar formation. Differences noted between new and mature scars demonstrate progression of tissue through inflammatory, proliferative, and remodeling phases of wound healing. Understanding these differences may allow physicians to tailor treatments more accurately, ensuring that interventions are targeted, effective, and promote optimal healing.