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<p>Rosacea remains challenging in both differential diagnosis and severity assessment. Laser Speckle Imaging (LSI), a non-invasive modality for real-time blood perfusion measurement, offers a novel approach to objectively evaluate this condition. Comparative facial imaging was conducted using VISIA and LSI systems. Rosacea patients completed standardized assessments: Patient Self-Assessment (PSA), Investigator’s Global Assessment (IGA), Clinical Erythema Assessment (CEA), and Global Flushing Severity Score (GFSS). We analyzed correlations between mean perfusion units (mPU), VISIA Red Area Score (VRAS), and clinical severity scores, with subgroup analysis by rosacea subtype. A three-round diagnostic study was conducted to explore the differential diagnostic capability of LSI. Thirty-seven patients with rosacea and 38 with other dermatoses were enrolled. A significant association between mPU and VRAS (<i>β</i> = 0.054, r<sup>2</sup> = 0.195, <i>p</i> &lt; 0.05) was revealed. Compared to VRAS, mPU showed stronger associations with all clinical severity scales (<i>p</i> &lt; 0.05). Erythematotelangiectatic rosacea (ETR) exhibited higher mPU than sensitive skin syndrome (SSS) (<i>p</i> &lt; 0.05). Diagnostic accuracy progressively improved across three assessment rounds (<i>p</i> &lt; 0.001), with LSI significantly enhancing discrimination between rosacea and SSS. LSI demonstrates clinically meaningful correlations with rosacea severity metrics and improves differentiation between rosacea and other inflammatory facial dermatoses, showing the potential as an objective assessment tool in rosacea management.</p>

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Laser speckle imaging: an objective approach for non-invasive evaluation and differential diagnosis of Rosacea

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Hongjie Luo,
  • Yukun Wang,
  • Deyu Song,
  • Xinjin Liu,
  • Lu Zhang,
  • Xian Jiang

摘要

Rosacea remains challenging in both differential diagnosis and severity assessment. Laser Speckle Imaging (LSI), a non-invasive modality for real-time blood perfusion measurement, offers a novel approach to objectively evaluate this condition. Comparative facial imaging was conducted using VISIA and LSI systems. Rosacea patients completed standardized assessments: Patient Self-Assessment (PSA), Investigator’s Global Assessment (IGA), Clinical Erythema Assessment (CEA), and Global Flushing Severity Score (GFSS). We analyzed correlations between mean perfusion units (mPU), VISIA Red Area Score (VRAS), and clinical severity scores, with subgroup analysis by rosacea subtype. A three-round diagnostic study was conducted to explore the differential diagnostic capability of LSI. Thirty-seven patients with rosacea and 38 with other dermatoses were enrolled. A significant association between mPU and VRAS (β = 0.054, r2 = 0.195, p < 0.05) was revealed. Compared to VRAS, mPU showed stronger associations with all clinical severity scales (p < 0.05). Erythematotelangiectatic rosacea (ETR) exhibited higher mPU than sensitive skin syndrome (SSS) (p < 0.05). Diagnostic accuracy progressively improved across three assessment rounds (p < 0.001), with LSI significantly enhancing discrimination between rosacea and SSS. LSI demonstrates clinically meaningful correlations with rosacea severity metrics and improves differentiation between rosacea and other inflammatory facial dermatoses, showing the potential as an objective assessment tool in rosacea management.